Title:
NOVEL CORONAVIRUS CHIMERIC NUCLEIC ACID VACCINE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/217206
Kind Code:
A1
Abstract:
A polynucleotide, a related product thereof, a use thereof in the preparation of a novel coronavirus vaccine, and a chimeric nucleic acid vaccine or immunogenic composition based on the polynucleotide; the polynucleotide encodes a recombinant chimeric antigen directly series-connecting or connecting via a linker: a novel coronavirus prototype S protein RBD domain to a Beta variant S protein RBD domain, or a Delta variant S protein RBD domain to a Beta variant S protein RBD domain, or a Delta variant S protein RBD domain to an Omicron variant S protein RBD domain; the chimeric nucleic acid vaccine based on the polynucleotide can provide relatively strong immune protection efficacy for various novel coronavirus strains, and when sequential immunization is performed with other types of vaccines, can induce a significant increase to immune response level for various strains of the novel coronavirus (i.e., broad-spectrum).
Inventors:
GAO FU (CN)
WANG QIHUI (CN)
DAI LIANPAN (CN)
DU PEI (CN)
CHEN QIAN (CN)
MA XUEHUI (CN)
WANG QIHUI (CN)
DAI LIANPAN (CN)
DU PEI (CN)
CHEN QIAN (CN)
MA XUEHUI (CN)
Application Number:
PCT/CN2023/093373
Publication Date:
November 16, 2023
Filing Date:
May 11, 2023
Export Citation:
Assignee:
INST MICROBIOLOGY CAS (CN)
International Classes:
C07K19/00; A61K39/215; A61K39/295; A61P31/14; C12N15/62
Domestic Patent References:
| WO2021239147A1 | 2021-12-02 | |||
| WO2021254270A1 | 2021-12-23 | |||
| WO2022003155A1 | 2022-01-06 |
Foreign References:
| CN114989308A | 2022-09-02 | |||
| CN114369172A | 2022-04-19 | |||
| CN111592602A | 2020-08-28 | |||
| CN114395569A | 2022-04-26 |
Other References:
CHEN QIAN, DU PEI, HAN YUXUAN, MA XUEHUI, ZHANG RONG, RONG XIAOYU, ZHAO XU, MA RENYI, YANG HUITING, ZHENG ANQI, HUANG QINGRUI, YAN: "Rapid evaluation of heterologous chimeric RBD-dimer mRNA vaccine for currently-epidemic Omicron sub-variants as booster shot after inactivated vaccine", BIOSAFETY AND HEALTH, vol. 5, no. 2, 1 April 2023 (2023-04-01), pages 89 - 100, XP093109118, ISSN: 2590-0536, DOI: 10.1016/j.bsheal.2023.02.002
XU KUN, GAO PING, LIU SHENG, LU SHUAIYAO, LEI WENWEN, ZHENG TIANYI, LIU XUEYUAN, XIE YUFENG, ZHAO ZHENNAN, GUO SHUXIN, TANG CONG, : "Protective prototype-Beta and Delta-Omicron chimeric RBD-dimer vaccines against SARS-CoV-2", CELL, ELSEVIER, AMSTERDAM NL, vol. 185, no. 13, 1 June 2022 (2022-06-01), Amsterdam NL , pages 2265 - 2278.e14, XP093109133, ISSN: 0092-8674, DOI: 10.1016/j.cell.2022.04.029
HAN YUXUAN, AN YALING, CHEN QIAN, XU KUN, LIU XUEYUAN, XU SENYU, DUAN HUIXIN, VOGEL ANNETTE B., ŞAHIN UĞUR, WANG QIHUI, DAI LIANPA: "mRNA vaccines expressing homo-prototype/Omicron and hetero-chimeric RBD-dimers against SARS-CoV-2", CELL RESEARCH CHINA, vol. 32, no. 11, pages 1022 - 1025, XP093109135, ISSN: 1748-7838, DOI: 10.1038/s41422-022-00720-z
XU KUN, GAO PING, LIU SHENG, LU SHUAIYAO, LEI WENWEN, ZHENG TIANYI, LIU XUEYUAN, XIE YUFENG, ZHAO ZHENNAN, GUO SHUXIN, TANG CONG, : "Protective prototype-Beta and Delta-Omicron chimeric RBD-dimer vaccines against SARS-CoV-2", CELL, ELSEVIER, AMSTERDAM NL, vol. 185, no. 13, 1 June 2022 (2022-06-01), Amsterdam NL , pages 2265 - 2278.e14, XP093109133, ISSN: 0092-8674, DOI: 10.1016/j.cell.2022.04.029
HAN YUXUAN, AN YALING, CHEN QIAN, XU KUN, LIU XUEYUAN, XU SENYU, DUAN HUIXIN, VOGEL ANNETTE B., ŞAHIN UĞUR, WANG QIHUI, DAI LIANPA: "mRNA vaccines expressing homo-prototype/Omicron and hetero-chimeric RBD-dimers against SARS-CoV-2", CELL RESEARCH CHINA, vol. 32, no. 11, pages 1022 - 1025, XP093109135, ISSN: 1748-7838, DOI: 10.1038/s41422-022-00720-z
Attorney, Agent or Firm:
BEIJING YUEHE INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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