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Title:
NOVEL CRISPR-CAS12I SYSTEMS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/138685
Kind Code:
A1
Abstract:
Provided are Cas12i polypeptides, fusion proteins comprising such Cas12i polypeptides, CRISPR-Cas12i systems comprising such Cas12i polypeptides or fusion proteins, and methods of using the same.

Inventors:
ZHANG HAINAN (CN)
ZHOU JINGXING (CN)
WANG HAOQIANG (CN)
ZHANG WEIHONG (CN)
Application Number:
PCT/CN2023/073420
Publication Date:
July 27, 2023
Filing Date:
January 20, 2023
Export Citation:
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Assignee:
HUIDAGENE THERAPEUTICS CO LTD (CN)
International Classes:
C12N9/22; C12N15/11
Domestic Patent References:
WO2021202800A12021-10-07
WO2021183807A12021-09-16
WO2021216674A12021-10-28
Foreign References:
CN113151215A2021-07-23
CN112195164A2021-01-08
US20200332275A12020-10-22
Other References:
ZHANG HAINAN, KONG XIANGFENG, XUE MINGXING, WANG ZIKANG, WEI YINGHUI, WANG HAOQIANG, ZHOU JINGXING, ZHANG WEIHONG, XU MENGQIU, SHE: "An engineered xCas12i with high activity, high specificity and broad PAM range", BIORXIV, 17 June 2022 (2022-06-17), XP093064016, [retrieved on 20230714], DOI: 10.1101/2022.06.15.496255
ZHANG BO, LUO DIYIN, LI YU, PERČULIJA VANJA, CHEN JING, LIN JINYING, YE YANGMIAO, OUYANG SONGYING: "Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1", NATURE COMMUNICATIONS, vol. 12, no. 1, 9 June 2021 (2021-06-09), XP055968167, DOI: 10.1038/s41467-021-23876-5
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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