NOVEL CRYSTAL OF BENZODIAZEPINE DERIVATIVE

Title:

NOVEL CRYSTAL OF BENZODIAZEPINE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/1995/001964

Kind Code:

A1

Abstract:

A type B crystal of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-tolyl)urea. It is produced by conducting recrystallization in a solvent mixture composed of 5 parts by volume of alcohol and at least 1 part by volume of water. It is so excellent in filterability and flow that it is extremely easy to filter in the mass production thereof and to handle in the production of a pharmaceutical preparation therefrom, thus being useful in the industrial production thereof.

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Inventors:

NAKAMURA MAKOTO (JP)
WATANABE KOUICHI (JP)

Application Number:

PCT/JP1994/001094

Publication Date:

January 19, 1995

Filing Date:

July 05, 1994

Export Citation:

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Assignee:

YAMANOUCHI PHARMA CO LTD (JP)
NAKAMURA MAKOTO (JP)
WATANABE KOUICHI (JP)

International Classes:

C07D243/24; (IPC1-7): C07D243/24; A61K31/55

Domestic Patent References:

WO1992011246A1

1992-07-09

Other References: