Title:
NOVEL CRYSTAL FORM OF MIDOSTAURIN, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/142914
Kind Code:
A1
Abstract:
The invention relates to novel crystal forms A, B and C of midostaurin, a preparation method therefor and the use thereof. The crystal forms have excellent properties in terms of physical and chemical stability and processing adaptability; and the crystallization process is simple and convenient to operate, and industrial production can be realized.
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Inventors:
ZHENG JIANFENG (CN)
SHI ZHENJUAN (CN)
LI NA (CN)
SU DI (CN)
CHEN LIANWEI (CN)
ZHAO MEIYU (CN)
SHI ZHENJUAN (CN)
LI NA (CN)
SU DI (CN)
CHEN LIANWEI (CN)
ZHAO MEIYU (CN)
Application Number:
PCT/CN2021/133470
Publication Date:
July 07, 2022
Filing Date:
November 26, 2021
Export Citation:
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
International Classes:
C07D498/22; A61K31/553; A61P35/00; A61P35/02
Domestic Patent References:
| WO2020200945A1 | 2020-10-08 | |||
| WO2020261293A1 | 2020-12-30 | |||
| WO2019215759A1 | 2019-11-14 | |||
| WO2018165071A1 | 2018-09-13 |
Foreign References:
| JPH05247055A | 1993-09-24 | |||
| US5093330A | 1992-03-03 | |||
| EP0296110A2 | 1988-12-21 | |||
| CN101010082A | 2007-08-01 | |||
| CN111393454A | 2020-07-10 | |||
| CN102639538A | 2012-08-15 | |||
| CN101048416A | 2007-10-03 | |||
| CN112812129A | 2021-05-18 |
Other References:
WANG LIPING;ZHUANG YIBIN;SUN KUNLAI;ZHU WEIMING: "Synthesis and Cytotoxicity of Halogenated Derivatives of PKC-412", CHINESE JOURNAL OF ORGANIC CHEMISTRY, vol. 34, no. 8, 15 August 2014 (2014-08-15), pages 1603 - 1608, XP055948888, ISSN: 0253-2786, DOI: 10.6023/cjoc201403046
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