Title:
NOVEL CRYSTAL OF MONOHYDRATE OF HETEROCYCLIC BIS(PHOSPHONIC ACID) DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1994/000462
Kind Code:
A1
Abstract:
Crystal D or E of 1-hydroxy-2-(imidazo[1,2-a]-pyridin-3-yl)ethane-1,1-bis(phosphonic acid) monohydrate having specified lattice spacing and relative intensity in the powder X-ray diffraction spectrum obtained by using Cu-Kalpha radiation and a dehydration peak temperature of 135-149 �C or 160-170 �C according to TG-DSC thermogravimetric analysis; and a solid pharmaceutical preparation containing the same. The crystals are useful for producing a stable solid preparation of the above compound which has an excellent drug efficacy for diseases wherein increased bone resorption participates, such as osteoporosis.
Inventors:
ISOMURA YASUO (JP)
TAKEUCHI MAKOTO (JP)
HAMADA MAMORU (JP)
KANEKO YOSHISABURO (JP)
YAMAMOTO NORIYA (JP)
TAKEUCHI MAKOTO (JP)
HAMADA MAMORU (JP)
KANEKO YOSHISABURO (JP)
YAMAMOTO NORIYA (JP)
Application Number:
PCT/JP1993/000821
Publication Date:
January 06, 1994
Filing Date:
June 18, 1993
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD (JP)
ISOMURA YASUO (JP)
TAKEUCHI MAKOTO (JP)
HAMADA MAMORU (JP)
KANEKO YOSHISABURO (JP)
YAMAMOTO NORIYA (JP)
ISOMURA YASUO (JP)
TAKEUCHI MAKOTO (JP)
HAMADA MAMORU (JP)
KANEKO YOSHISABURO (JP)
YAMAMOTO NORIYA (JP)
International Classes:
A61K31/675; C07F9/6561; (IPC1-7): C07F9/6561; A61K31/675
Foreign References:
| JPH02138288A | 1990-05-28 | |||
| JPH02138288A | 1990-05-28 |
Other References:
See also references of EP 0647649A4
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