Title:
NOVEL CRYSTAL OF STILBENE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/2001/068587
Kind Code:
A1
Abstract:
A IV-form crystal of (Z)-N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serine amide hydrochloride which can be obtained through a crystallization step employing a solvent containing at most 2 wt.% water and which, when examined by X-ray powder diffractometry, gives a pattern having peaks at least at 13.4°, 18.7°, 19.4°, and 22.5° (2$g(u)). This compound is useful as an active ingredient for a carcinostatic agent. By the process, a crystal is obtained which has excellent properties desirable from the standpoint of the production of medicinal products, i.e., considerably reduced moisture adsorption and extremely high stability to water. Also provided are a process for producing the IV-form crystal and a method of using the crystal.
Inventors:
TAKAHASHI SHINICHIRO (JP)
SUGAWARA YOKO (JP)
MATSUEDA HIROYUKI (JP)
SUGAWARA YOKO (JP)
MATSUEDA HIROYUKI (JP)
Application Number:
PCT/JP2001/002028
Publication Date:
September 20, 2001
Filing Date:
March 14, 2001
Export Citation:
Assignee:
AJINOMOTO KK (JP)
TAKAHASHI SHINICHIRO (JP)
SUGAWARA YOKO (JP)
MATSUEDA HIROYUKI (JP)
TAKAHASHI SHINICHIRO (JP)
SUGAWARA YOKO (JP)
MATSUEDA HIROYUKI (JP)
International Classes:
A61K31/167; A61P35/00; C07C231/24; C07C237/08; (IPC1-7): C07C237/04; C07C231/24; A61K31/167; A61P35/00
Other References:
OHSUMI K. ET AL.: "Synthesis and antitumor activities of amino acid prodrugs of amino-combretastatins", ANTI-CANCER DRUG DESIGN, vol. 14, no. 6, 1999, pages 539 - 548, XP002938076
Attorney, Agent or Firm:
Ishida, Yasumasa (Bohsei Building 7th floor, 20-12,
Shin-Yokohama 3-chome, Kohoku-k, Yokohama-shi Kanagawa, JP)
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