NOVEL CRYSTALLINE POLYMORPHIC FORMS OF LERCANIDIPINE HYDROCHLORIDE AND PROCESS FOR THEIR PREPARATION

Title:

NOVEL CRYSTALLINE POLYMORPHIC FORMS OF LERCANIDIPINE HYDROCHLORIDE AND PROCESS FOR THEIR PREPARATION

Document Type and Number:

WIPO Patent Application WO/2003/014084

Kind Code:

A1

Abstract:

The invention describes novel lercanidipine crude Forms (A) and (B), novel lercanidipine hydrochloride crystalline Forms (I) and (II) obtained form said crude Forms, pharmaceutical, antihypertensive compositions containing as active agent at least one of the lercanidipine hydrochloride crystalline Forms (I) and (II) and methods of use thereof

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Inventors:

BONIFACIO FAUSTO
CAMPANA FRANCESCO
DE IASI GIANLUCA
LEONARDI AMEDEO

Application Number:

PCT/EP2002/008699

Publication Date:

February 20, 2003

Filing Date:

August 05, 2002

Export Citation:

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Assignee:

RECORDATI IRELAND LTD (IE)

International Classes:

A61K31/44; A61K31/4422; A61P9/12; B01D9/02; C07D211/90; (IPC1-7): C07D211/90; A61K31/44; A61P9/12

Domestic Patent References:

WO1997003669A1	1997-02-06
WO1996035668A1	1996-11-14

Foreign References:

US5767136A	1998-06-16
US0596139A	1897-12-28
US4705797A	1987-11-10

Other References:

LEONARDI, AMEDEO ET AL: "Asymmetric N-(3,3-diphenylpropyl)aminoalkyl esters of 4-aryl-2,6-dimethyl 1,4-dihydropyridine-3,5-dicarboxylic acids with antihypertensive activity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (1998), 33(5), 399-420, XP004127371
MCCLELLAN K J ET AL: "LERCANIDIPINE A REVIEW OF ITS USE IN HYPERTENSION", DRUGS, ADIS INTERNATIONAL LTD, AT, vol. 5, no. 60, November 2000 (2000-11-01), pages 1123 - 1140, XP008001723, ISSN: 0012-6667

Attorney, Agent or Firm:

Gervasi, Gemma (Corso di Porta Vittoria 9, Milan, IT)

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