Title:
NOVEL CYCLOSPORINS
Document Type and Number:
WIPO Patent Application WO2004082629
Kind Code:
A3
Abstract:
The compounds of the present invention are represented by the chemical structure found in Formula I: where A is an amino acid of Formula II: or a pharmaceutically acceptable salt thereof, with R0, R1, B, C, D, E, F, G, H, I, J, and K defined herein.
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Inventors:
MOLINO BRUCE F
HAYDAR SIMON N
YANG ZHICAI
MICHELS PETER C
HEMENWAY MICHAEL S
RICH JOSEPH O
KHMELNITSKY YURI
HAYDAR SIMON N
YANG ZHICAI
MICHELS PETER C
HEMENWAY MICHAEL S
RICH JOSEPH O
KHMELNITSKY YURI
Application Number:
PCT/US2004/008118
Publication Date:
December 01, 2005
Filing Date:
March 16, 2004
Export Citation:
Assignee:
ALBANY MOLECULAR RES INC (US)
International Classes:
A61K6/00; A61K38/00; A61K38/13; C07K1/113; C07K7/64; C12P21/04; A61K; (IPC1-7): A61K38/00
Foreign References:
| US4885276A | 1989-12-05 |
Other References:
OFFENZELLER M. ET AL: "Biosynthesis of the Unusual Amino Acid (4R)-4-[(E)-2-Butenyl]-4-methyl-L-threonine of Cyclosporin A: Enzymatic Analysis of the Reaction Sequence Including Identification of the Methylation Precursor ina Polyketide Pathway", BIOCHEMISTRY, vol. 35, no. 25, 25 June 1996 (1996-06-25), pages 8401 - 8412, XP002991592
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