Title:
NOVEL DELIVERY OF HYDROXY CARBOXYLIC ACIDS
Document Type and Number:
WIPO Patent Application WO1999045933
Kind Code:
A9
Abstract:
The present invention provides greater than 99 % pure bis(triorganosilyl)hydroxycarboxylates of the general formulae: R3SiO-CHR<1>-COO-SiR3 and R3SiO-CHR<1>-R<2>COO-SiR3 wherein each R is independently a monovalent straight or branched chain alkyl or alkenyl group having from 1 to about 6 carbon atoms, or an aryl group, R<1> may be hydrogen, a monovalent straight or branched chain alkyl group having from 1 to about 18 carbon atoms, or an aryl group, and R<2> is a divalent straight or branched chain alkyl group having from 1 to about 18 carbon atoms, an aryl group, or a straight or branched chain alkaryl group having from 7 to about 18 carbon atoms; a process for producing the bis(trimethylsilyl)-hydroxycarboxylates comprising the trimethylsilylation with hexamethyldisilazane of the corresponding hydroxy carboxylic acids; cosmetic formulation comprising the greater than 99 % pure bis(trimethylsilyl)hydroxycarboxylates dissolved in aprotic media; and a method of delivering hydroxycarbxylic acids to the epidermis without apparent irritation or inflammation of the epidermis or stratum corneum.
Inventors:
LEGROW GARY E
TERRY W LEONARD JR
TERRY W LEONARD JR
Application Number:
PCT/US1999/005200
Publication Date:
November 18, 1999
Filing Date:
March 10, 1999
Export Citation:
Assignee:
PCR (US)
International Classes:
A01N55/00; A61K8/55; A61K6/00; A61K8/00; A61K8/06; A61K8/58; A61K8/89; A61K8/891; A61K31/695; A61K31/74; A61P17/00; A61P43/00; A61Q19/00; A61Q19/08; (IPC1-7): A61K31/695
Download PDF: