NOVEL DERIVATIVE HAVING INHIBITORY ACTIVITY AGAINST 11Β-HSD1, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

WIPO Patent Application WO/2011/149213

A2

The present invention relates to a novel derivative having inhibitory activity against 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), a preparation method thereof, and a pharmaceutical composition containing the same as an active ingredient. The compound according to the present invention selectively inhibits 11β-HSD1, and thus can be used as a therapeutic agent for treating diseases caused by over-activation of 11β-HSD1, for example, non-insulin dependent diabetes mellitus (type II diabetes), insulin resistance, obesity, lipid disorders, metabolic syndrome, and diseases and state mediated by the action of excessive glucocorticoid.

HAN CHEOL KYU (KR)
AUH JIN (KR)
HAN CHANG KYUN (KR)
YOON JEONG HYEOK (KR)
KIM NAM DOO (KR)
KIM TAE JEONG (KR)
LEE YOUN HO (KR)
JEONG HYEON GUN (KR)
SHIN YOUNG JUNE (KR)
KWAK HO YOUNG (KR)
HAN DONG-OH (KR)

PCT/KR2011/003656

December 01, 2011

May 17, 2011

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EQUISNZAROO CO LTD (KR)
AHNGOOK PHARM CO LTD (KR)
HAN CHEOL KYU (KR)
AUH JIN (KR)
HAN CHANG KYUN (KR)
YOON JEONG HYEOK (KR)
KIM NAM DOO (KR)
KIM TAE JEONG (KR)
LEE YOUN HO (KR)
JEONG HYEON GUN (KR)
SHIN YOUNG JUNE (KR)
KWAK HO YOUNG (KR)
HAN DONG-OH (KR)

A61K31/18; A61K31/16; A61P3/04; A61P3/10; C07C237/04; C07C311/03

WO2000063165A1

2000-10-26

KR20070068432A	2007-06-29
US20050245533A1	2005-11-03

LEE, WON HEE (KR)
이원희 (KR)

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