Title:
NOVEL DIHYDROPYRANOPYRIMIDINONE DERIVATIVES, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/099424
Kind Code:
A1
Abstract:
The present invention relates to a novel dihydropyranopyrimidinone derivative, a tautomer thereof, a stereoisomer thereof and their mixture, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating a tankyrase-related disease, which contains the same as an active ingredient.
More Like This:
Inventors:
KIM KYUNGJIN (KR)
KIM UK-IL (KR)
YOON JI HYE (KR)
KIM UK-IL (KR)
YOON JI HYE (KR)
Application Number:
PCT/KR2016/014061
Publication Date:
June 15, 2017
Filing Date:
December 01, 2016
Export Citation:
Assignee:
ST PHARM CO LTD (KR)
International Classes:
C07D491/052; A61K31/497; A61K31/519; A61K31/5377; C07D401/14; C07D403/04; C07D413/14
Domestic Patent References:
| WO2013010092A1 | 2013-01-17 |
Foreign References:
| JP2014520858A | 2014-08-25 | |||
| JP2014522855A | 2014-09-08 |
Other References:
LAU, T. ET AL.: "A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth", CANCER RES., vol. 73, no. 10, 2013, pages 3132 - 3144, XP055390391
NKIZINKIKO, Y. ET AL.: "Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics", BIOORG MED CHEM., vol. 23, no. 15, pages 4139 - 4149, XP055390392
WAHLBERT ET AL., NAT. BIOTECHNOL., vol. 30, no. 3, 2012, pages 283 - 288
CHIANG ET AL., PLOS ONE, vol. 3, no. 7, 2008, pages e2639
HUANG ET AL., NATURE, vol. 461, no. 7264, 2009, pages 614 - 620
WAALER ET AL., CANCER RES., vol. 72, no. 11, 2012, pages 2822 - 2832
MIYAKI ET AL., CANCER RES., vol. 73, no. 10, 2013, pages 3132 - 3144
TANIGUCHI ET AL., ONCOGENE, vol. 21, 2002, pages 4863 - 4871
LIU ET AL., NAT. GENET., vol. 26, 2000, pages 146 - 147
NATURE CHEMICAL BIOLOGY, vol. 5, 2009, pages 100
CHANG ET AL., BIOCHEM. J., vol. 391, 2005, pages 177 - 184
CHI ET AL., J. BIOL. CHEM., vol. 275, 2000, pages 38437 - 38444
BAE ET AL., J. BIOL. CHEM., vol. 278, 2003, pages 5195 - 5204
SHULTZ ET AL., J. MED, CHEM., vol. 56, no. 16, 2013, pages 6495 - 6511
NKIZINKIKO, Y. ET AL.: "Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics", BIOORG MED CHEM., vol. 23, no. 15, pages 4139 - 4149, XP055390392
WAHLBERT ET AL., NAT. BIOTECHNOL., vol. 30, no. 3, 2012, pages 283 - 288
CHIANG ET AL., PLOS ONE, vol. 3, no. 7, 2008, pages e2639
HUANG ET AL., NATURE, vol. 461, no. 7264, 2009, pages 614 - 620
WAALER ET AL., CANCER RES., vol. 72, no. 11, 2012, pages 2822 - 2832
MIYAKI ET AL., CANCER RES., vol. 73, no. 10, 2013, pages 3132 - 3144
TANIGUCHI ET AL., ONCOGENE, vol. 21, 2002, pages 4863 - 4871
LIU ET AL., NAT. GENET., vol. 26, 2000, pages 146 - 147
NATURE CHEMICAL BIOLOGY, vol. 5, 2009, pages 100
CHANG ET AL., BIOCHEM. J., vol. 391, 2005, pages 177 - 184
CHI ET AL., J. BIOL. CHEM., vol. 275, 2000, pages 38437 - 38444
BAE ET AL., J. BIOL. CHEM., vol. 278, 2003, pages 5195 - 5204
SHULTZ ET AL., J. MED, CHEM., vol. 56, no. 16, 2013, pages 6495 - 6511
Attorney, Agent or Firm:
AHN, So Young (KR)
Download PDF:
Previous Patent: METHOD FOR PREPARING SUPER-ABSORBENT RESIN
Next Patent: MOBILE TERMINAL AND OPERATION METHOD THEREFOR
Next Patent: MOBILE TERMINAL AND OPERATION METHOD THEREFOR