Title:
NOVEL DIHYDROPYRIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1999/032446
Kind Code:
A1
Abstract:
A dihydropyridine derivative represented by formula (I), analogues thereof and medicinally acceptable salts of both exhibit a selective blocking activity against N-type calcium channel, and are therefore useful as therapeutic agents for various diseases related to N-type calcium channel.
Inventors:
NIWA SEIJI (JP)
OHNO SEIJI (JP)
ONISHI TOMOYUKI (JP)
KITO MORIKAZU (JP)
TAKAHARA AKIRA (JP)
ONO YUKITSUGU (JP)
UNEYAMA HISAYUKI (JP)
OHNO SEIJI (JP)
ONISHI TOMOYUKI (JP)
KITO MORIKAZU (JP)
TAKAHARA AKIRA (JP)
ONO YUKITSUGU (JP)
UNEYAMA HISAYUKI (JP)
Application Number:
PCT/JP1998/005801
Publication Date:
July 01, 1999
Filing Date:
December 22, 1998
Export Citation:
Assignee:
AJINOMOTO KK (JP)
NIWA SEIJI (JP)
OHNO SEIJI (JP)
ONISHI TOMOYUKI (JP)
KITO MORIKAZU (JP)
TAKAHARA AKIRA (JP)
ONO YUKITSUGU (JP)
UNEYAMA HISAYUKI (JP)
NIWA SEIJI (JP)
OHNO SEIJI (JP)
ONISHI TOMOYUKI (JP)
KITO MORIKAZU (JP)
TAKAHARA AKIRA (JP)
ONO YUKITSUGU (JP)
UNEYAMA HISAYUKI (JP)
International Classes:
C07D211/90; C07D401/12; C07D405/04; C07D491/04; C07D521/00; (IPC1-7): C07D211/90; C07D401/12; C07D405/12; C07D498/04; A61K31/445; A61K31/495; A61K31/535
Domestic Patent References:
| WO1994022829A2 | 1994-10-13 |
Foreign References:
| JPS62175462A | 1987-08-01 |
Other References:
SAINANI J. B., SHAH A. C., ARYA V. P.: "FORMATION OF 1,4,5,6,7,8-HEXAHYDRO-PYRIDO¬4,3-B¾PYRIDINE BY HANTZSCH SYNTHESIS.", INDIAN JOURNAL OF CHEMISTRY, JODHPUR, IN, vol. 34B., 1 January 1995 (1995-01-01), IN, pages 17 - 20., XP002920347
SADANANDAM Y. S., ET AL.: "SYNTHESIS AND PHARMACOLOGY OF NEW 1,4-DIHYDROPYRIDINES. 2,6-DIMETHYL-4-(SUBSTITUTED PHENYL) OR (2-FURYL)-, (2-THIENYL)- OR (3-PYRIDYL)-3,5-DI¬N-METHYL) OR (N-DIETHYL)¾CARBAMOYL-1,4-DIHYDROPYRIDINES AS POTENT CALCIUM-CHANNEL BLOCKERS.", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY., EDITIONS SCIENTIFIQUE ELSEVIER, PARIS., FR, vol. 29., 1 January 1994 (1994-01-01), FR, pages 975 - 979., XP002920348, ISSN: 0223-5234, DOI: 10.1016/0223-5234(94)90198-8
See also references of EP 1043314A4
SADANANDAM Y. S., ET AL.: "SYNTHESIS AND PHARMACOLOGY OF NEW 1,4-DIHYDROPYRIDINES. 2,6-DIMETHYL-4-(SUBSTITUTED PHENYL) OR (2-FURYL)-, (2-THIENYL)- OR (3-PYRIDYL)-3,5-DI¬N-METHYL) OR (N-DIETHYL)¾CARBAMOYL-1,4-DIHYDROPYRIDINES AS POTENT CALCIUM-CHANNEL BLOCKERS.", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY., EDITIONS SCIENTIFIQUE ELSEVIER, PARIS., FR, vol. 29., 1 January 1994 (1994-01-01), FR, pages 975 - 979., XP002920348, ISSN: 0223-5234, DOI: 10.1016/0223-5234(94)90198-8
See also references of EP 1043314A4
Attorney, Agent or Firm:
Nakamura, Minoru (Marunouchi 3-chome Chiyoda-ku Tokyo, JP)
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