Title:
NOVEL DRUG DELIVERY CONJUGATED MOIETY FOR ORAL ADMINISTRATION OF DRUG UNSUITABLE FOR ORAL ADMINISTRATION AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/014332
Kind Code:
A1
Abstract:
The present invention provides a novel drug delivery conjugated moiety for oral administration of a drug that is not suitable for oral administration or a pharmaceutically acceptable salt thereof. When the drug delivery conjugated moiety of the present invention or a pharmaceutically acceptable salt thereof is combined with a drug, which is not suitable for oral administration, and is administered orally, it exhibits an excellent absorption rate without decreasing the biological activities of the drug. Moreover, the drug delivery conjugated moiety of the present invention or a pharmaceutically acceptable salt thereof can be easily prepared in a few steps, which is very advantageous in terms of mass production.
Inventors:
KIM KYUNGJIN (KR)
YUN JISUK (KR)
JUNG HYUKJUN (KR)
LEE MYUNGYUN (KR)
NAM HWAJUNG (KR)
JEON OK-CHEOL (KR)
YUN JISUK (KR)
JUNG HYUKJUN (KR)
LEE MYUNGYUN (KR)
NAM HWAJUNG (KR)
JEON OK-CHEOL (KR)
Application Number:
PCT/KR2015/007516
Publication Date:
January 26, 2017
Filing Date:
July 20, 2015
Export Citation:
Assignee:
ST PHARM CO LTD (KR)
International Classes:
C07C401/00; A61K31/727; A61K38/26; A61K38/28
Foreign References:
| US20140363371A1 | 2014-12-11 |
Other References:
JUNTAO LUO ET AL.: "Well-defined, size-tunable, multifunctional micelles for efficient paclitaxel delivery for cancer treatment", BIOCONJUGATE CHEM., vol. 21, 2010, pages 1216 - 1224, XP055196709
ELINA SIEVAENEN: "Exploitation of bile acid transport systems in prodrug design", MOLECULES, vol. 12, 2007, pages 1859 - 1889, XP055351707
VACLAV JANOUT ET AL.: "Molecular umbrella conjugate for the ocular delivery of siRNA", BIOCONJUGATE CHEM., vol. 25, 2014, pages 197 - 201, XP055351708
YU SHAO ET AL.: "Photo and redox dual responsive reversibly cross-linked nanocarrier for efficient tumor-targeted drug delivery", ACS APPL. MATER. INTERFACES, vol. 6, 2014, pages 10381 - 10392, XP055351710
YIYUN CHENG ET AL.: "Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives", CHEM. SOC. REV., vol. 40, 2011, pages 2673 - 2703, XP055240107
See also references of EP 3277663A4
ELINA SIEVAENEN: "Exploitation of bile acid transport systems in prodrug design", MOLECULES, vol. 12, 2007, pages 1859 - 1889, XP055351707
VACLAV JANOUT ET AL.: "Molecular umbrella conjugate for the ocular delivery of siRNA", BIOCONJUGATE CHEM., vol. 25, 2014, pages 197 - 201, XP055351708
YU SHAO ET AL.: "Photo and redox dual responsive reversibly cross-linked nanocarrier for efficient tumor-targeted drug delivery", ACS APPL. MATER. INTERFACES, vol. 6, 2014, pages 10381 - 10392, XP055351710
YIYUN CHENG ET AL.: "Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives", CHEM. SOC. REV., vol. 40, 2011, pages 2673 - 2703, XP055240107
See also references of EP 3277663A4
Attorney, Agent or Firm:
AHN, So Young (KR)
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