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Title:
NOVEL EP4 AGONIST
Document Type and Number:
WIPO Patent Application WO/2011/111714
Kind Code:
A1
Abstract:
Disclosed are: a compound which has excellent metabolic stability and selectively binds to EP4 receptor; and a pharmaceutical product which contains the compound. Specifically disclosed is a compound represented by formula (1) (wherein R1 and R2 each independently represents a hydrogen atom or a linear alkyl group having 1-3 carbon atoms, and R3 represents a hydrogen atom, an alkyl group having 1-4 carbon atoms, an alkoxyalkyl group, an aryl group, a halogen atom or a halogenated alkyl group) or a pharmaceutically acceptable salt thereof, which is different from publicly known PGI2s and has a selective EP4 agonist action. Consequently, a pharmaceutical product which contains the compound is useful for prophylaxis and/or treatment of immune diseases, cardiovascular diseases, heart diseases, respiratory diseases, eye diseases, kidney diseases, hepatic diseases, bone diseases, digestive tract diseases, neurological diseases, skin diseases and the like.

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Inventors:
MURATA TAKAHIKO (JP)
AMAKAWA MASAHIRO (JP)
TERADAIRA SHIN (JP)
MATSUMURA YASUSHI (JP)
KONISHI KATSUHIKO (JP)
Application Number:
PCT/JP2011/055411
Publication Date:
September 15, 2011
Filing Date:
March 08, 2011
Export Citation:
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Assignee:
KAKEN PHARMA CO LTD (JP)
ASAHI GLASS CO LTD (JP)
MURATA TAKAHIKO (JP)
AMAKAWA MASAHIRO (JP)
TERADAIRA SHIN (JP)
MATSUMURA YASUSHI (JP)
KONISHI KATSUHIKO (JP)
International Classes:
A61K31/41; A61P1/02; A61P1/04; A61P1/16; A61P7/00; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P15/00; A61P17/02; A61P17/06; A61P17/14; A61P19/00; A61P19/02; A61P19/10; A61P21/02; A61P25/00; A61P27/02; A61P27/06; A61P27/16; A61P29/00; A61P37/02; A61P37/04; A61P43/00; C07D405/06
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WO1998013356A11998-04-02
WO1997017974A11997-05-22
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US7402605B22008-07-22
JPH07330752A1995-12-19
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See also references of EP 2545917A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
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