Title:
NOVEL EPIGALLOCATECHIN GALLATE TETRAMER, AND VASCULAR ENDOTHELIAL FUNCTION IMPROVER COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2010/024393
Kind Code:
A1
Abstract:
Disclosed is a compound which can be ingested in a sustained manner and has an activity to improve the vascular endothelial function through the enhancement of the activity of NO produced in vascular endothelial cells or the like.
Specifically disclosed is a compound represented by formula (I) [wherein R1, R2, R3 and R4 independently represent H or a gallate group] or a salt thereof. Also disclosed is a vascular endothelial function improver, a food, a beverage or a pharmaceutical composition containing the compound.
Inventors:
FUKUI YUKO (JP)
IMAMOTO MAI (JP)
IMAMOTO MAI (JP)
Application Number:
PCT/JP2009/065084
Publication Date:
March 04, 2010
Filing Date:
August 28, 2009
Export Citation:
Assignee:
SUNTORY HOLDINGS LTD (JP)
FUKUI YUKO (JP)
IMAMOTO MAI (JP)
FUKUI YUKO (JP)
IMAMOTO MAI (JP)
International Classes:
A23L1/30; C07D311/62; A23L2/52; A61K31/353; A61P3/06; A61P3/10; A61P9/10; A61P9/12
Domestic Patent References:
| WO2005116005A1 | 2005-12-08 | |||
| WO2005116005A1 | 2005-12-08 |
Foreign References:
| JPH02187433A | 1990-07-23 | |||
| JPH10142726A | 1998-05-29 | |||
| JP2009001531A | 2009-01-08 |
Other References:
LORENZ, M. ET AL.: "A Constituent of Green Tea, Epigallocatechin-3-gallate, Activates Endotherial Nitric Oxide Synthetase by a Phosphatidylinositol-3-OH-kinase-, c-AMP- dependent Protein Kinase-, and Akt-dependent Pathway and Leads to Endothelial-dependent Vasorelaxation", THE JOURNAL OF BIOLOGOCAL CHEMISTRY, vol. 279, no. 7, 2004, pages 6190 - 6195, XP008144768
DUFFY, S.J. ET AL.: "Short-and Long-Term Black Tea Consumption Reverses Endothelial Dysfunction in Patients With Coronary Artery Disease", CIRCULATION, vol. 104, 2001, pages 151 - 156, XP008144769
ANTER, E. ET AL.: "Activation of Endothelial Nitric-oxide Synthase by the p38 MAPK in Response to Black Tea Polyphenols", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 45, 2004, pages 46637 - 46643, XP008144770
KUBARA, B. K. ET AL.: "Kola acuminata proanthocyanidins: a class of anti-trypanosomal compounds effective against Trypanosoma brucei", INTERNATIONAL JOURNAL FOR PARASITOLOGY, vol. 35, no. 1, 2005, pages 91 - 103, XP004690106
KULIEV, Z. A. ET AL.: "Oligomeric proanthocyanidin glycosides of Clementsia semenovii and their biological activity. III", CHEMISTRY OF NATURAL COMPOUNDS (TRANSLATION OF KHIMIYA PRIRODNYKH SOEDINENII), vol. 36, no. 1, 2000, pages 60 - 67, XP008144771
FOLIA PHARMACOL. JPN., vol. 125, 2005, pages 285 - 290
JOURNAL OF CLINICAL INVESTIGATION, vol. 95, 1995, pages 1747 - 1755
ENDOCRINOLOGY, vol. 148, 2007, pages 3773 - 3780
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, 2004, pages 6190 - 6195
CIRCULATION., vol. 104, 2001, pages 156
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, 2004, pages 46637 - 46643
CHEM. PHARM. BULL., vol. 37, no. 12, 1989, pages 3255 - 3263
J. AGRIC. FOOD CHEM., vol. 53, 2005, pages 4593 - 4598
CHEM. PHARM. BULL, vol. 37, no. 12, 1989, pages 3255 - 3563
HASHIMOTO, F. NONAKA; G. NISHIOKA, I., CHEM. PHARM. BULL., vol. 36, no. 5, 1988, pages 1676 - 1684
See also references of EP 2330103A4
DUFFY, S.J. ET AL.: "Short-and Long-Term Black Tea Consumption Reverses Endothelial Dysfunction in Patients With Coronary Artery Disease", CIRCULATION, vol. 104, 2001, pages 151 - 156, XP008144769
ANTER, E. ET AL.: "Activation of Endothelial Nitric-oxide Synthase by the p38 MAPK in Response to Black Tea Polyphenols", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 45, 2004, pages 46637 - 46643, XP008144770
KUBARA, B. K. ET AL.: "Kola acuminata proanthocyanidins: a class of anti-trypanosomal compounds effective against Trypanosoma brucei", INTERNATIONAL JOURNAL FOR PARASITOLOGY, vol. 35, no. 1, 2005, pages 91 - 103, XP004690106
KULIEV, Z. A. ET AL.: "Oligomeric proanthocyanidin glycosides of Clementsia semenovii and their biological activity. III", CHEMISTRY OF NATURAL COMPOUNDS (TRANSLATION OF KHIMIYA PRIRODNYKH SOEDINENII), vol. 36, no. 1, 2000, pages 60 - 67, XP008144771
FOLIA PHARMACOL. JPN., vol. 125, 2005, pages 285 - 290
JOURNAL OF CLINICAL INVESTIGATION, vol. 95, 1995, pages 1747 - 1755
ENDOCRINOLOGY, vol. 148, 2007, pages 3773 - 3780
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, 2004, pages 6190 - 6195
CIRCULATION., vol. 104, 2001, pages 156
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, 2004, pages 46637 - 46643
CHEM. PHARM. BULL., vol. 37, no. 12, 1989, pages 3255 - 3263
J. AGRIC. FOOD CHEM., vol. 53, 2005, pages 4593 - 4598
CHEM. PHARM. BULL, vol. 37, no. 12, 1989, pages 3255 - 3563
HASHIMOTO, F. NONAKA; G. NISHIOKA, I., CHEM. PHARM. BULL., vol. 36, no. 5, 1988, pages 1676 - 1684
See also references of EP 2330103A4
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
Ono Shinjiro (JP)
Download PDF:
Previous Patent: MANUFACTURING METHOD FOR SILICON CARBIDE MONOCRYSTALS
Next Patent: OPTICAL WAVEGUIDE, OPTO-ELECTRIC HYBRID BOARD, AND OPTICAL MODULE
Next Patent: OPTICAL WAVEGUIDE, OPTO-ELECTRIC HYBRID BOARD, AND OPTICAL MODULE