Title:
NOVEL FARNESYL PROTEIN TRANSFERASE INHIBITORS AS ANTITUMOR AGENTS
Document Type and Number:
WIPO Patent Application WO2005014577
Kind Code:
A9
Abstract:
Disclosed are novel tricyclic compounds of the formula (I) and a pharmaceutically acceptable salts or solvates thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Also disclosed are uses of the compounds of formula (I) for the manufacture of a medicament for the treatment of cancer.
Inventors:
ZHU HUGH Y (US)
COOPER ALAN B (US)
DESAI JAGDISH A (US)
WANG JAMES J-S (US)
RANE DINANATH F (US)
DOLL RONALD J (US)
NJOROGE F GEORGE (US)
GIRIJAVALLABHAN VIYYOOR M (US)
COOPER ALAN B (US)
DESAI JAGDISH A (US)
WANG JAMES J-S (US)
RANE DINANATH F (US)
DOLL RONALD J (US)
NJOROGE F GEORGE (US)
GIRIJAVALLABHAN VIYYOOR M (US)
Application Number:
PCT/US2004/025042
Publication Date:
March 23, 2006
Filing Date:
August 04, 2004
Export Citation:
Assignee:
SCHERING CORP (US)
ZHU HUGH Y (US)
COOPER ALAN B (US)
DESAI JAGDISH A (US)
WANG JAMES J-S (US)
RANE DINANATH F (US)
DOLL RONALD J (US)
NJOROGE F GEORGE (US)
GIRIJAVALLABHAN VIYYOOR M (US)
ZHU HUGH Y (US)
COOPER ALAN B (US)
DESAI JAGDISH A (US)
WANG JAMES J-S (US)
RANE DINANATH F (US)
DOLL RONALD J (US)
NJOROGE F GEORGE (US)
GIRIJAVALLABHAN VIYYOOR M (US)
International Classes:
A61P35/00; C07D401/06; (IPC1-7): C07D401/06; C07D401/14; A61K31/415; A61P35/00
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