Title:
NOVEL FARNESYL PROTEIN TRANSFERASE INHIBITORS AND THEIR USE TO TREAT CANCER
Document Type and Number:
WIPO Patent Application WO2006065828
Kind Code:
A3
Abstract:
Disclosed are compounds of the formula: wherein R8 represents a cyclic and acyclic moiety to which is bound an imidazolylalkyl group; R9 represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
Inventors:
RANE DINANATH (US)
Application Number:
PCT/US2005/045098
Publication Date:
August 10, 2006
Filing Date:
December 12, 2005
Export Citation:
Assignee:
SCHERING CORP (US)
RANE DINANATH (US)
RANE DINANATH (US)
International Classes:
A61K31/55; A61P35/00; C07D491/04
Domestic Patent References:
| WO1998057960A1 | 1998-12-23 | |||
| WO2002080895A2 | 2002-10-17 | |||
| WO2002056884A2 | 2002-07-25 | |||
| WO2000037459A1 | 2000-06-29 | |||
| WO1996031478A1 | 1996-10-10 |
Foreign References:
| US5672611A | 1997-09-30 | |||
| US5712280A | 1998-01-27 |
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