Title:
NOVEL FATTY ACID ANALOGUES FOR THE TREATMENT OF PRIMARY AND SECONDARY RESTENOSIS
Document Type and Number:
WIPO Patent Application WO1999058123
Kind Code:
A3
Abstract:
The present invention relates to novel fatty acid analogues of the general formula (I): CH3 -[CH2]m - [xi - CH2]n - COOR, wherein n is an integer from 1 to 12, and wherein m is an integer from 0 to 23, and wherein i is an odd number which indicates the position relative to COOR, and wherein Xi independent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and wherein R represents hydrogen or C1-C4 alkyl, with the proviso that at least one of the Xi is not CH2, or a salt, prodrug or complex thereof, for the preparation of a pharmaceutical composition for the treatment and/or prevention of primary and/or secondary stenosis. Further the present invention relates to the use of said compounds for the prevention and/or treatment of a disease caused by procedural vascular trauma and/or pathological proliferation of smooth muscle cells, and/or an increased level of plasma homocysteine.
Inventors:
BERGE ROLF (NO)
Application Number:
PCT/NO1999/000149
Publication Date:
March 09, 2000
Filing Date:
May 07, 1999
Export Citation:
Assignee:
THIA MEDICA AS (NO)
BERGE ROLF (NO)
BERGE ROLF (NO)
International Classes:
A23D9/007; A23L1/30; A23L33/00; A23L33/20; A61K31/19; A61K31/20; A61K31/215; A61K31/22; A61K31/23; A61K31/255; A61K31/265; A61K31/28; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P43/00; C07C323/51; C07C323/52; C07C327/06; C07C391/00; A61K; (IPC1-7): A61K31/19; A61K31/20
Domestic Patent References:
| WO1997003663A1 | 1997-02-06 |
Foreign References:
| EP0345038A2 | 1989-12-06 |
Other References:
STN INTERNATIONAL, File CAPLUS, CAPLUS Accession No. 1996:312821, Document No. 125:75989, ASIEDU DANIEL K. et al., "long- term effect of tetradecylthioacetic acid: a study on plasma lipid profile and fatty composition and oxidation in different rat organs".
E. DYROY ET AL.: "The Influence of a Novel Antioxidant Fatty Acid on the Development of Stenosis After Ballon Injury", LIPIDS,, vol. 34, 1999, pages 339
E. DYROY ET AL.: "The Influence of a Novel Antioxidant Fatty Acid on the Development of Stenosis After Ballon Injury", LIPIDS,, vol. 34, 1999, pages 339
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