Title:
NOVEL FUSED-RING CARBOXYLIC ACID COMPOUND OR SALT THEREOF, AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/1995/033720
Kind Code:
A1
Abstract:
A novel fused-ring carboxylic acid compound represented by general formula (I) or a pharmacologically acceptable salt thereof; a medicinal composition thereof; and a medicinal use thereof, wherein each symbol is as defined in the specification. The compound and salt have an excellent GPIIb/IIIa antagonism against mammals including humans, can be administered orally, have a long life in blood and a low toxicity, and are reduced in side effects, thus being very useful for preventing or treating thrombotic diseases.
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Inventors:
ONO SHINICHIRO (JP)
YOSHIDA TOMOHIRO (JP)
ASHIMORI ATSUYUKI (JP)
KOSAKA KEIGO (JP)
OKADA TAKEHIRO (JP)
MAEDA KAZUHIRO (JP)
EDA MASAHIRO (JP)
MORI FUMIO (JP)
INOUE YOSHIHISA (JP)
EBISU HAJIME (JP)
IMADA TERUAKI (JP)
IKEGAWA RURIKO (JP)
WANG FENG (JP)
NAKAMURA NORIFUMI (JP)
YOSHIDA TOMOHIRO (JP)
ASHIMORI ATSUYUKI (JP)
KOSAKA KEIGO (JP)
OKADA TAKEHIRO (JP)
MAEDA KAZUHIRO (JP)
EDA MASAHIRO (JP)
MORI FUMIO (JP)
INOUE YOSHIHISA (JP)
EBISU HAJIME (JP)
IMADA TERUAKI (JP)
IKEGAWA RURIKO (JP)
WANG FENG (JP)
NAKAMURA NORIFUMI (JP)
Application Number:
PCT/JP1995/001119
Publication Date:
December 14, 1995
Filing Date:
June 06, 1995
Export Citation:
Assignee:
GREEN CROSS CORP (JP)
ONO SHINICHIRO (JP)
YOSHIDA TOMOHIRO (JP)
ASHIMORI ATSUYUKI (JP)
KOSAKA KEIGO (JP)
OKADA TAKEHIRO (JP)
MAEDA KAZUHIRO (JP)
EDA MASAHIRO (JP)
MORI FUMIO (JP)
INOUE YOSHIHISA (JP)
EBISU HAJIME (JP)
IMADA TERUAKI (JP)
IKEGAWA RURIKO (JP)
WANG FENG (JP)
NAKAMURA NORIFUMI (JP)
ONO SHINICHIRO (JP)
YOSHIDA TOMOHIRO (JP)
ASHIMORI ATSUYUKI (JP)
KOSAKA KEIGO (JP)
OKADA TAKEHIRO (JP)
MAEDA KAZUHIRO (JP)
EDA MASAHIRO (JP)
MORI FUMIO (JP)
INOUE YOSHIHISA (JP)
EBISU HAJIME (JP)
IMADA TERUAKI (JP)
IKEGAWA RURIKO (JP)
WANG FENG (JP)
NAKAMURA NORIFUMI (JP)
International Classes:
C07D209/42; C07D307/84; C07D307/85; C07D333/62; C07D333/68; C07D491/04; C07D491/048; (IPC1-7): C07D209/42; C07D307/85; C07D333/62; C07D401/12; C07D405/12; C07D409/12; C07D491/052; C08B37/16; A61K31/34; A61K31/38; A61K31/40; A61K31/44; A61K31/445; A61K47/40; A61K31/435
Other References:
J. MED. CHEM., 23(7), 787-95 (1980).
J. MED. CHEM., 21(7), 613-22 (1978).
ANTIMICROB. AGENTS. CHEMOTHER., 18(2), 231-9 (1980).
INVEST. NEW DRUGS, 1(2), 103-15 (1983).
See also references of EP 0712844A4
J. MED. CHEM., 21(7), 613-22 (1978).
ANTIMICROB. AGENTS. CHEMOTHER., 18(2), 231-9 (1980).
INVEST. NEW DRUGS, 1(2), 103-15 (1983).
See also references of EP 0712844A4
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