Title:
NOVEL FUSION PROTEIN COMPRISING TRANSCRIPTION MODULATION DOMAIN OF P65 AND PROTEIN TRANSPORT DOMAIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/119521
Kind Code:
A1
Abstract:
The invention relates to a new fusion protein comprising a transcription modulation domain of p65 which is a subunit of the transcription factor NF-κB, and a protein transport domain and a use thereof. The fusion protein according to the present invention has the effects of inhibiting the transcription of NF-κB and IL-2 by competitive inhibition, inhibiting the secretion of inflammatory cytokines by LPS, and inhibiting the production of IL-2, IFN-γ, IL-4, IL-17A and IL-10 in splenocytes, and thus can be useful as a composition for the prevention or treatment of NF-κB hyperactivity-related diseases.
Inventors:
LEE SANG KYOU (KR)
PARK SUNG DONG (KR)
YANG JUNG-JIN (KR)
PARK SUNG DONG (KR)
YANG JUNG-JIN (KR)
Application Number:
PCT/KR2016/000104
Publication Date:
July 13, 2017
Filing Date:
January 06, 2016
Export Citation:
Assignee:
LEE SANG KYOU (KR)
International Classes:
C07K19/00; A61K38/17; A61P31/00; A61P37/00; C07K14/435; C12N15/62
Foreign References:
| KR20120017913A | 2012-02-29 |
Other References:
DATABASE GenBank [O] 15 February 2015 (2015-02-15), XP055398104, Database accession no. NP_033071.1
HERMOSO, MARCELA A. ET AL.: "Putting the Brake on Inflammatory Responses: the Role of Glucocorticoids", IUBMB LIFE, vol. 55, no. 9, September 2003 (2003-09-01), pages 497 - 504, XP055398102
KINYANJUI, MARGARET W. ET AL.: "Cell -penetrating Peptides and Proteins: New Inhibitors of Allergic Airways Disease", CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 86, no. 1-2, 16 January 2008 (2008-01-16), pages 1 - 7
DATABASE GenBank [O] 6 October 2010 (2010-10-06), XP055398107, Database accession no. BAE32727.1
PARK, SUNG-DONG ET AL.: "Intranuclear Interactomic Inhibition of NF-kB Suppresses LPS-induced Severe Sepsis", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 464, 6 July 2015 (2015-07-06), pages 711 - 717, XP029255642
PARK, SUNG-DONG ET AL.: "Therapeutic Effect ofTransducible Smad3 and p65 Transcription Modulation Domain in Tnflammatory Diseases", MASTER'S THESIS OF YONSEI UNIVERSITY, 1 August 2015 (2015-08-01), pages 1 - 140
HERMOSO, MARCELA A. ET AL.: "Putting the Brake on Inflammatory Responses: the Role of Glucocorticoids", IUBMB LIFE, vol. 55, no. 9, September 2003 (2003-09-01), pages 497 - 504, XP055398102
KINYANJUI, MARGARET W. ET AL.: "Cell -penetrating Peptides and Proteins: New Inhibitors of Allergic Airways Disease", CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 86, no. 1-2, 16 January 2008 (2008-01-16), pages 1 - 7
DATABASE GenBank [O] 6 October 2010 (2010-10-06), XP055398107, Database accession no. BAE32727.1
PARK, SUNG-DONG ET AL.: "Intranuclear Interactomic Inhibition of NF-kB Suppresses LPS-induced Severe Sepsis", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 464, 6 July 2015 (2015-07-06), pages 711 - 717, XP029255642
PARK, SUNG-DONG ET AL.: "Therapeutic Effect ofTransducible Smad3 and p65 Transcription Modulation Domain in Tnflammatory Diseases", MASTER'S THESIS OF YONSEI UNIVERSITY, 1 August 2015 (2015-08-01), pages 1 - 140
Attorney, Agent or Firm:
YANG, Boo Hyun (KR)
Download PDF: