Title:
NOVEL GALACTOSIDE INHIBITOR OF GALECTINS
Document Type and Number:
WIPO Patent Application WO/2019/137971
Kind Code:
A1
Abstract:
The present invention relates to a compound of the general formula (I) wherein the pyranose ring is a-D-galactopyranose, R1 is selected from the group consisting of (II) wherein the asterix 1 * indicates the carbon atom of the heteroaromatic ring that is covalently attached to the triazole group of formula (I). The compound of formula (I) is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-1 to a ligand in a mammal, such as a human.
Inventors:
ZETTERBERG FREDRIK (SE)
Application Number:
PCT/EP2019/050467
Publication Date:
July 18, 2019
Filing Date:
January 09, 2019
Export Citation:
Assignee:
GALECTO BIOTECH AB (DK)
International Classes:
A61K31/7056; C07H19/056; A61P11/00; A61P35/00
Domestic Patent References:
| WO2016120403A1 | 2016-08-04 | |||
| WO2018011093A1 | 2018-01-18 | |||
| WO2005113569A1 | 2005-12-01 | |||
| WO2005113568A1 | 2005-12-01 | |||
| WO2010126435A1 | 2010-11-04 | |||
| WO2014067986A1 | 2014-05-08 | |||
| WO2016120403A1 | 2016-08-04 |
Foreign References:
| EP1256586A1 | 2002-11-13 | |||
| US20070185041A1 | 2007-08-09 | |||
| US7638623B2 | 2009-12-29 | |||
| US20140099319A1 | 2014-04-10 |
Other References:
T. DELAINE, CHEMBIOCHEM, 2016
MELERO ET AL., NATURE REVIEWS CANCER, 2015
SORME, P.; KAHL-KNUTSSON, B.; HUFLEJT, M.; NILSSON, U. J.; LEFFLER H.: "Fluorescence polarization as an analytical tool to evaluate galectin-ligand interactions", ANAL. BIOCHEM., vol. 334, 2004, pages 36 - 47, XP004583732, DOI: doi:10.1016/j.ab.2004.06.042
SALOMONSSON, EMMA; LARUMBE, AMAIA; TEJLER, JOHAN; TULLBERG, ERIK; RYDBERG, HANNA; SUNDIN, ANDERS; KHABUT, AREEJ; FREJD, TORBJORN;, BIOCHEMISTRY, vol. 49, no. 44, 2010, pages 9518 - 9532
MELERO ET AL., NATURE REVIEWS CANCER, 2015
SORME, P.; KAHL-KNUTSSON, B.; HUFLEJT, M.; NILSSON, U. J.; LEFFLER H.: "Fluorescence polarization as an analytical tool to evaluate galectin-ligand interactions", ANAL. BIOCHEM., vol. 334, 2004, pages 36 - 47, XP004583732, DOI: doi:10.1016/j.ab.2004.06.042
SALOMONSSON, EMMA; LARUMBE, AMAIA; TEJLER, JOHAN; TULLBERG, ERIK; RYDBERG, HANNA; SUNDIN, ANDERS; KHABUT, AREEJ; FREJD, TORBJORN;, BIOCHEMISTRY, vol. 49, no. 44, 2010, pages 9518 - 9532
Attorney, Agent or Firm:
LBKPATENT APS (DK)
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