NOVEL 18Α-GLYCYRRHETINIC ACID DERIVATIVE AND PHARMACEUTICAL USE THEREOF - CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD

Title:

NOVEL 18Α-GLYCYRRHETINIC ACID DERIVATIVE AND PHARMACEUTICAL USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2016/184400

Kind Code:

A1

Abstract:

The present invention relates to a novel 18α-glycyrrhetinic acid derivative and pharmaceutical use thereof. The compound has a weak inhibitory activity on 11β-hydroxyl steroid dehydrogenase, thus effectively alleviating an adrenocortical hormone-like adverse effects of glycyrrhetinic acid medicine, and reducing risk of water and sodium retention.

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Inventors:

ZHANG XIQUAN (CN)
ZHANG AIMING (CN)
XU HONGJIANG (CN)
DONG PING (CN)
ZHOU HAO (CN)
TIAN XIN (CN)

Application Number:

PCT/CN2016/082646

Publication Date:

November 24, 2016

Filing Date:

May 19, 2016

Export Citation:

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Assignee:

CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)

International Classes:

C07J63/00; A61K31/56; A61P1/16; A61P31/14

Foreign References:

JPH0782155A	1995-03-28
JP2009062322A	2009-03-26
GB870651A	1961-06-14
CN104250278A	2014-12-31
CN1762967A	2006-04-26
CN101486751A	2009-07-22

Other References:

BIAN, RULIAN ET AL.: "Pharmacological Research of Choline Salt of Glycyrrhetinic Acid", JOURNAL OF ZHEJIANG MEDICAL UNIVERSITY, vol. 11, no. 6, 31 December 1982 (1982-12-31), pages 272 - 274

Attorney, Agent or Firm:

BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
北京三友知识产权代理有限公司 (CN)

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