NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES

Title:

NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/2000/075113

Kind Code:

A1

Abstract:

Nitrogenous six-membered heterocycle compounds bearing as the substituents -X-A-R?3¿, -N-(R?1¿)-(R?2¿-substituted Ph) and -CONH¿2?; salts or prodrugs thereof; and Syk inhibitors containing the compounds, the salts or the prodrugs as the active ingredient, wherein A is (substituted) lower alkylene, (substituted) arylene, or the like; X is NR?4¿, CONR?4¿, NR?4¿CO, O, or S; R?1¿ and R?4¿ are each H, lower alkyl, -CO-lower alkyl, or -SO¿2?-lower alkyl; R?2¿ is H, (substituted) lower alkyl, -O-lower alkyl, -S-lower alkyl, -O-aryl, nitro, cyano, or the like; and R?3¿ is -CO¿2?H, -CO¿2?-lower alkyl, -lower alkylene-CO¿2?H, -NH¿2?, -alkylene-NH¿2?, or the like.

Inventors:

HISAMICHI HIROYUKI (JP)
KAWAZOE SOUICHIROU (JP)
TANABE KAZUHITO (JP)
ICHIKAWA ATSUSHI (JP)
ORITA AKIKO (JP)
SUZUKI TAKAYUKI (JP)
ONDA KENICHI (JP)
TAKEUCHI MAKOTO (JP)

Application Number:

PCT/JP2000/003767

Publication Date:

December 14, 2000

Filing Date:

June 09, 2000

Export Citation:

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Assignee:

YAMANOUCHI PHARMA CO LTD (JP)
HISAMICHI HIROYUKI (JP)
KAWAZOE SOUICHIROU (JP)
TANABE KAZUHITO (JP)
ICHIKAWA ATSUSHI (JP)
ORITA AKIKO (JP)
SUZUKI TAKAYUKI (JP)
ONDA KENICHI (JP)
TAKEUCHI MAKOTO (JP)

International Classes:

A61P29/00; A61P37/08; A61P43/00; C07D213/82; C07D239/48; C07D241/26; C07D253/07; (IPC1-7): C07D213/82; C07D239/48; C07D241/26; A61K31/455; A61K31/505; A61K31/4965; A61P37/08; A61P29/00; A61P43/00

Domestic Patent References:

WO1999031073A1	1999-06-24
WO1995017888A1	1995-07-06

Foreign References:

JPH0776562A

1995-03-20

Other References: