Title:
NOVEL HETEROCYCLYL-PHENYL-METHYLAMINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF FOR PREVENTION, ALLEVIATION, OR TREATMENT OF MULTIPLE SCLEROSIS
Document Type and Number:
WIPO Patent Application WO/2024/029638
Kind Code:
A1
Abstract:
The present invention relates to a series of novel heterocyclyl-phenyl-methylamine derivatives, a preparation method therefor, and a use thereof for prevention, alleviation, or treatment of multiple sclerosis.
Inventors:
PARK KI DUK (KR)
PARK JONG HYUN (KR)
PARK SUN JUN (KR)
KIM YOOWON (KR)
KIM HYEON JEONG (KR)
KIM SI WON (KR)
KIM JUSHIN (KR)
CHOI JI WON (KR)
KIM BYUNG EUN (KR)
LEE ELIJAH HWEJIN (KR)
PARK JONG HYUN (KR)
PARK SUN JUN (KR)
KIM YOOWON (KR)
KIM HYEON JEONG (KR)
KIM SI WON (KR)
KIM JUSHIN (KR)
CHOI JI WON (KR)
KIM BYUNG EUN (KR)
LEE ELIJAH HWEJIN (KR)
Application Number:
PCT/KR2022/011333
Publication Date:
February 08, 2024
Filing Date:
August 01, 2022
Export Citation:
Assignee:
KOREA INST SCI & TECH (KR)
International Classes:
C07D421/10; A23K20/137; A23L33/10; A61K31/095; A61P25/00; A61P37/00; C07D293/06; C07D413/10; C07D413/14; C07D421/14
Foreign References:
| KR20140114340A | 2014-09-26 | |||
| KR20110044873A | 2011-05-02 | |||
| US20110263661A1 | 2011-10-27 |
Other References:
DATABASE Registry 25 February 2022 (2022-02-25), ANONYMOUS: "3-Azetidinecarboxylic acid, 1-[[4-[5-[3-chloro-4-(1-methylethoxy)phenyl]- 4,5-dihydro-3-isoxazolyl]phenyl]methyl]- (CA INDEX NAME)", XP093135245, retrieved from STNext Database accession no. 2760666-19-9
JAN PATRICK DELA CRUZ CALUPITAN; OLIVIER GALANGAU; OLIVIER GUILLERMET; ROLAND CORATGER; TAKUYA NAKASHIMA; GWÉNAËL RAPENNE; TSUYOSH: "Synthesis and Photochromism of Chloro‐ and tert‐Butyl‐Functionalized Terarylene Derivatives for Surface Deposition", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WILEY-VCH, DE, vol. 2017, no. 17, 3 May 2017 (2017-05-03), DE , pages 2451 - 2461, XP072112273, ISSN: 1434-193X, DOI: 10.1002/ejoc.201601657
PARK SUN JUN, YEON SEUL KI, KIM YOOWON, KIM HYEON JEONG, KIM SIWON, KIM JUSHIN, CHOI JI WON, KIM BYUNGEUN, LEE ELIJAH HWEJIN, KIM : "Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 65, no. 4, 24 February 2022 (2022-02-24), US , pages 3539 - 3562, XP093134672, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c01979
JAN PATRICK DELA CRUZ CALUPITAN; OLIVIER GALANGAU; OLIVIER GUILLERMET; ROLAND CORATGER; TAKUYA NAKASHIMA; GWÉNAËL RAPENNE; TSUYOSH: "Synthesis and Photochromism of Chloro‐ and tert‐Butyl‐Functionalized Terarylene Derivatives for Surface Deposition", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WILEY-VCH, DE, vol. 2017, no. 17, 3 May 2017 (2017-05-03), DE , pages 2451 - 2461, XP072112273, ISSN: 1434-193X, DOI: 10.1002/ejoc.201601657
PARK SUN JUN, YEON SEUL KI, KIM YOOWON, KIM HYEON JEONG, KIM SIWON, KIM JUSHIN, CHOI JI WON, KIM BYUNGEUN, LEE ELIJAH HWEJIN, KIM : "Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 65, no. 4, 24 February 2022 (2022-02-24), US , pages 3539 - 3562, XP093134672, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c01979
Attorney, Agent or Firm:
HANOL INTELLECTUAL PROPERTY & LAW (KR)
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