Title:
A NOVEL HUMAN GENE-LOC344967 RELATED WITH NASOPHARYNGEAL CARCINOMA AND THE PROTEIN IT ENCODES
Document Type and Number:
WIPO Patent Application WO/2008/009179
Kind Code:
A1
Abstract:
A novel human gene -LOC344967, which is closely related with nasopharyngeal carcinoma's occurring and development and it is widely expressed in many human tissues, NPC biopsy specimen and NPC cell lines. When it is highly expressed in nasopharyngeal carcinoma cell lines, such as NP69, C666-1, CNE-2 tissues, it can lead to apoptosis's occurring, showing that it has important biological function. LOC344967 can be used as a new target to diagnose and treat nasopharyngeal carcinoma and other types of tumors.
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Inventors:
ZENG YIXIN
Application Number:
PCT/CN2006/002212
Publication Date:
January 24, 2008
Filing Date:
August 28, 2006
Export Citation:
Assignee:
SUN YAT SEN UNIVERSITY CANCER (CN)
ZENG YIXIN
ZENG YIXIN
International Classes:
C12N15/55; A61P35/00; C07K16/00; C12N9/14; C12N15/63; C12Q1/68
Foreign References:
| CN1643377A | 2005-07-20 |
Other References:
DATABASE GENBANK [online] accession no. EMBL Database accession no. (AK125299)
JIANG R.-C. ET AL.: "A Functional Variant in the Transcriptional Regulatory Region of Gene LOC344967 Cosegregates with Disease Phenotype in Familial Nasopharyngeal Carcinoma", CANCER RES., vol. 66, no. 2, 15 January 2006 (2006-01-15)
LADEANA W. ET AL.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4", NATURE, vol. 434, 7 April 2005 (2005-04-07)
JUNJI YAMADA ET AL.: "Human brain acyl-CoA hydrolase isoforms encoded by a single gene", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 299, 31 December 2002 (2002-12-31), pages 49 - 56
JIANG R.-C. ET AL.: "A Functional Variant in the Transcriptional Regulatory Region of Gene LOC344967 Cosegregates with Disease Phenotype in Familial Nasopharyngeal Carcinoma", CANCER RES., vol. 66, no. 2, 15 January 2006 (2006-01-15)
LADEANA W. ET AL.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4", NATURE, vol. 434, 7 April 2005 (2005-04-07)
JUNJI YAMADA ET AL.: "Human brain acyl-CoA hydrolase isoforms encoded by a single gene", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 299, 31 December 2002 (2002-12-31), pages 49 - 56
Attorney, Agent or Firm:
GUANGZHOU SCIHEAD PATENT AGENT CO., LTD. (Huihua Commercial & Trade BuildingNo. 80, XianLie Zhong Road,Guangzhou, Guangdong 0, CN)
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