Title:
NOVEL HUMAN GNRH RECEPTOR
Document Type and Number:
WIPO Patent Application WO2002070701
Kind Code:
A9
Abstract:
The invention concerns a gene coding for a novel human GnRH receptor (gonadotropin-releasing hormone receptor), hereafter referred to as GnR-R2. The DNA sequences of the invention can be placed in expression systems so as to produce GnRH-R2 and/or cell lines expressing GnRH and preferably responding to GnRH-induced transduction signals. Such cell lines can advantageously be used for screening and identifying novel GnRH agonists and antagonists. In other aspects of the invention, the DNA encoding GnRH-R2, antisense oligonucleotide sequences, GnRH-R2 expression products, antibodies against such products can be used in diagnostic methods or for treatment of disorders related to an abnormal expression of GnRH-R2, for example an overexpression, a subexpression or an expression of a mutant receptor. Transgenic animals containing the GnRH-R2 transgene can be used as models for evaluating analogues of GnRH in vivo.
Inventors:
FERRANDIS ERIC (FR)
THURIEAU CHRISTOPHE (FR)
THURIEAU CHRISTOPHE (FR)
Application Number:
PCT/FR2002/000741
Publication Date:
June 28, 2007
Filing Date:
March 01, 2002
Export Citation:
Assignee:
SOD CONSEILS RECH APPLIC (FR)
FERRANDIS ERIC (FR)
THURIEAU CHRISTOPHE (FR)
FERRANDIS ERIC (FR)
THURIEAU CHRISTOPHE (FR)
International Classes:
C07K14/72; C12N1/21; C12N15/12; G01N33/68; G01N33/74; G01N33/76; A61K38/00
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