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Title:
NOVEL HYDROXAMIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2011/132712
Kind Code:
A1
Abstract:
Provided is a novel compound that is useful as a medical drug in that said compound displays strong antimicrobial activity against gram-negative bacteria such as Pseudomonas aeruginosa and drug-resistant strains thereof, on the basis of LpxC-inhibiting activity. The novel compound is a hydroxamic acid derivative represented by general formula 1 (1) or a pharmaceutically acceptable salt thereof.

Inventors:
TAKASHIMA HAJIME (JP)
TSURUTA RISA (JP)
YABUUCHI TETSUYA (JP)
OKA YUSUKE (JP)
URABE HIROKI (JP)
SUGA YOICHIRO (JP)
TAKAHASHI MASATO (JP)
UNEUCHI FUMITO (JP)
KOTSUBO HIRONORI (JP)
SHOJI MUNEO (JP)
KAWAGUCHI YASUKO (JP)
Application Number:
PCT/JP2011/059737
Publication Date:
October 27, 2011
Filing Date:
April 20, 2011
Export Citation:
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Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
TOYAMA CHEMICAL CO LTD (JP)
TAKASHIMA HAJIME (JP)
TSURUTA RISA (JP)
YABUUCHI TETSUYA (JP)
OKA YUSUKE (JP)
URABE HIROKI (JP)
SUGA YOICHIRO (JP)
TAKAHASHI MASATO (JP)
UNEUCHI FUMITO (JP)
KOTSUBO HIRONORI (JP)
SHOJI MUNEO (JP)
KAWAGUCHI YASUKO (JP)
International Classes:
C07C259/06; A61K31/166; A61K31/337; A61K31/341; A61K31/343; A61K31/351; A61K31/357; A61K31/36; A61K31/381; A61K31/397; A61K31/40; A61K31/4015; A61K31/402; A61K31/403; A61K31/4035; A61K31/404; A61K31/4045; A61K31/407; A61K31/415; A61K31/416; A61K31/4164; A61K31/4184; A61K31/42; A61K31/421; A61K31/422; A61K31/4245; A61K31/426; A61K31/428; A61K31/433; A61K31/437; A61K31/438; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/445; A61K31/4453; A61K31/47; A61K31/496; A61K31/5375; A61K31/5377; A61K31/538; A61K31/5386; A61K31/54; A61K31/553; A61P31/04; A61P43/00; C07C323/62; C07D205/04; C07D205/12; C07D207/10; C07D207/12; C07D207/27; C07D207/327; C07D209/08; C07D209/12; C07D209/14; C07D209/44; C07D209/52; C07D211/14; C07D211/18; C07D211/38; C07D211/46; C07D211/56; C07D211/70; C07D213/38; C07D213/40; C07D213/54; C07D213/61; C07D213/64; C07D213/65; C07D213/70; C07D213/74; C07D213/81; C07D215/14; C07D217/04; C07D217/12; C07D231/12; C07D231/56; C07D233/61; C07D235/04; C07D257/04; C07D261/08; C07D263/14; C07D263/32; C07D263/56; C07D265/30; C07D265/38; C07D267/10; C07D271/12; C07D277/20; C07D277/30; C07D277/62; C07D277/66; C07D285/12; C07D295/08; C07D295/12; C07D295/14; C07D295/16; C07D305/06; C07D305/08; C07D307/14; C07D307/18; C07D307/52; C07D307/54; C07D307/78; C07D307/82; C07D307/87; C07D309/04; C07D309/14; C07D317/30; C07D317/60; C07D319/18; C07D319/20; C07D333/24; C07D405/06; C07D413/06; C07D471/04; C07D471/10; C07D487/08; C07D491/20; C07D498/08
Domestic Patent References:
WO2000059874A12000-10-12
WO2008154642A22008-12-18
WO2010031750A12010-03-25
WO2002030873A12002-04-18
WO2008045671A12008-04-17
WO2004058728A12004-07-15
WO2004062601A22004-07-29
WO2007069020A22007-06-21
WO2008154642A22008-12-18
WO2010031750A12010-03-25
WO2010017060A12010-02-11
WO2010032147A22010-03-25
WO2009007814A12009-01-15
Foreign References:
US20070066646A12007-03-22
JP2006519772A2006-08-31
US20100135960A12010-06-03
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See also references of EP 2562155A4
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
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