Title:
NOVEL IMMUNOMODULATORY, NEUROMODULATORY, OSTEOGENIC, AND ANTI-OSTEOPOROTIC HKUOT-S2 PROTEIN THAT ENHANCES BONE FRACTURE REPAIRS AND SUPPRESSES OSTEOPOROSIS DEVELOPMENT
Document Type and Number:
WIPO Patent Application WO/2024/032713
Kind Code:
A1
Abstract:
Provided are compositions comprising the HKUOT-S2 protein, at least one peptide according to at least one of SEQ ID NO: 81-97, or proteins comprising an amino acid sequence according to at least one of SEQ ID NO: 81-97. Provided are methods of osteogenesis, including, for example, enhancing bone repair, macrophage polarizations that regulate pro-inflammatory and anti-inflammatory activities, and bone resorption by osteoclasts and methods of treating inflammatory diseases, spinal cord injuries, liver and kidney diseases, cardiovascular diseases, diabetes, post-menopausal syndrome, infertility, or hematopoietic diseases or enhancing wound healing.
Inventors:
KUBI JOHN AKROFI (CN)
YEUNG WAI-KWOK KELVIN (CN)
BRAH AUGUSTINE SUURINOBAH (CN)
CHEUNG KENNETH MAN CHEE (CN)
YEUNG WAI-KWOK KELVIN (CN)
BRAH AUGUSTINE SUURINOBAH (CN)
CHEUNG KENNETH MAN CHEE (CN)
Application Number:
PCT/CN2023/112211
Publication Date:
February 15, 2024
Filing Date:
August 10, 2023
Export Citation:
Assignee:
UNIV HONG KONG (CN)
International Classes:
C07K14/415; A61K36/00; A61P1/16; A61P3/10; A61P9/00; A61P13/12; A61P19/00; A61P19/10
Foreign References:
| US20100129928A1 | 2010-05-27 | |||
| US20190298780A1 | 2019-10-03 | |||
| US20100047812A1 | 2010-02-25 | |||
| US20100159486A1 | 2010-06-24 | |||
| CN103945854A | 2014-07-23 |
Other References:
KUBI JOHN AKROFI, BRAH AUGUSTINE SUURINOBAH, CHEUNG KENNETH MAN CHEE, LEE YIN LAU, LEE KAI-FAI, SZE STEPHEN CHO WING, QIAO WEI, YE: "A new osteogenic protein isolated from Dioscorea opposita Thunb accelerates bone defect healing through the mTOR signaling axis", BIOACTIVE MATERIALS, vol. 27, 1 September 2023 (2023-09-01), pages 429 - 446, XP093140357, ISSN: 2452-199X, DOI: 10.1016/j.bioactmat.2023.04.018
DATABASE PROTEIN ANONYMOUS : "unnamed protein product [Arabidopsis arenosa]", XP093140370, retrieved from NCBI
DATABASE PROTEIN ANONYMOUS : "protocadherin Fat 2 [Protobothrops mucrosquamatus]", XP093140373, retrieved from NCBI
DATABASE PROTEIN ANONYMOUS : "threonine--tRNA ligase [Aggregatilinea lenta]", XP093140374, retrieved from NCBI
DATABASE PROTEIN ANONYMOUS : "hypothetical protein RF1 (chloroplast) [Chloranthus erectus]", XP093140376, retrieved from NCBI
DATABASE PROTEIN ANONYMOUS : "RNA polymerase beta'' subunit (chloroplast) [Buxus microphylla]", XP093140379, retrieved from NCBI
DATABASE PROTEIN ANONYMOUS : "hypothetical chloroplast RF1 (chloroplast) [Illicium oligandrum]", XP093140380, retrieved from NCBI
DATABASE PROTEIN ANONYMOUS : "PREDICTED: fibrinogen alpha chain [Bos indicus]", XP093140383, retrieved from NCBI
LOK WONG KAM, MING LAI YAU, LI KA WAN, FAI LEE KAI, NG TZI BUN, PAN CHEUNG HO, BO ZHANG YAN, LAO LIXING, NGOK-SHUN WONG RICKY, CHU: "A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 5, no. 1, US , XP093140360, ISSN: 2045-2322, DOI: 10.1038/srep10179
DATABASE PROTEIN ANONYMOUS : "unnamed protein product [Arabidopsis arenosa]", XP093140370, retrieved from NCBI
DATABASE PROTEIN ANONYMOUS : "protocadherin Fat 2 [Protobothrops mucrosquamatus]", XP093140373, retrieved from NCBI
DATABASE PROTEIN ANONYMOUS : "threonine--tRNA ligase [Aggregatilinea lenta]", XP093140374, retrieved from NCBI
DATABASE PROTEIN ANONYMOUS : "hypothetical protein RF1 (chloroplast) [Chloranthus erectus]", XP093140376, retrieved from NCBI
DATABASE PROTEIN ANONYMOUS : "RNA polymerase beta'' subunit (chloroplast) [Buxus microphylla]", XP093140379, retrieved from NCBI
DATABASE PROTEIN ANONYMOUS : "hypothetical chloroplast RF1 (chloroplast) [Illicium oligandrum]", XP093140380, retrieved from NCBI
DATABASE PROTEIN ANONYMOUS : "PREDICTED: fibrinogen alpha chain [Bos indicus]", XP093140383, retrieved from NCBI
LOK WONG KAM, MING LAI YAU, LI KA WAN, FAI LEE KAI, NG TZI BUN, PAN CHEUNG HO, BO ZHANG YAN, LAO LIXING, NGOK-SHUN WONG RICKY, CHU: "A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 5, no. 1, US , XP093140360, ISSN: 2045-2322, DOI: 10.1038/srep10179
Attorney, Agent or Firm:
LIU , SHEN & ASSOCIATES (CN)
Download PDF:
Previous Patent: METHOD EXECUTED BY USER EQUIPMENT, AND USER EQUIPMENT
Next Patent: METHOD PERFORMED BY USER EQUIPMENT AND USER EQUIPMENT
Next Patent: METHOD PERFORMED BY USER EQUIPMENT AND USER EQUIPMENT