Title:
NOVEL INDAZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2005/035506
Kind Code:
A1
Abstract:
To prepare a novel indazole derivative useful as a medicine and to find out a new pharmacological activity of the derivative. The compound is represented by the general formula [I] and has excellent Rho-kinase inhibitory activity. In the formula, ring X is a benzene ring or pyridine ring; R1 and R2 each is hydrogen or alkyl; R3 and R4 each is halogeno, hydrogen, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogeno, hydrogen, OH, alkoxy, aryloxy, alkyl, or aryl. These groups may be substituted.
Inventors:
HAGIHARA MASAHIKO (JP)
KOMORI KEN-ICHI (JP)
SUNAMOTO HIDETOSHI (JP)
NISHIDA HIROSHI (JP)
MATSUGI TAKESHI (JP)
NAKAJIMA TADASHI (JP)
HATANO MASAKAZU (JP)
KIDO KAZUTAKA (JP)
HARA HIDEAKI (JP)
KOMORI KEN-ICHI (JP)
SUNAMOTO HIDETOSHI (JP)
NISHIDA HIROSHI (JP)
MATSUGI TAKESHI (JP)
NAKAJIMA TADASHI (JP)
HATANO MASAKAZU (JP)
KIDO KAZUTAKA (JP)
HARA HIDEAKI (JP)
Application Number:
PCT/JP2004/015663
Publication Date:
April 21, 2005
Filing Date:
October 15, 2004
Export Citation:
Assignee:
UBE INDUSTRIES (JP)
SANTEN PHARMACEUTICAL CO LTD (JP)
HAGIHARA MASAHIKO (JP)
KOMORI KEN-ICHI (JP)
SUNAMOTO HIDETOSHI (JP)
NISHIDA HIROSHI (JP)
MATSUGI TAKESHI (JP)
NAKAJIMA TADASHI (JP)
HATANO MASAKAZU (JP)
KIDO KAZUTAKA (JP)
HARA HIDEAKI (JP)
SANTEN PHARMACEUTICAL CO LTD (JP)
HAGIHARA MASAHIKO (JP)
KOMORI KEN-ICHI (JP)
SUNAMOTO HIDETOSHI (JP)
NISHIDA HIROSHI (JP)
MATSUGI TAKESHI (JP)
NAKAJIMA TADASHI (JP)
HATANO MASAKAZU (JP)
KIDO KAZUTAKA (JP)
HARA HIDEAKI (JP)
International Classes:
A61K31/416; A61K31/4439; A61P27/06; A61P43/00; C07D231/56; C07D401/04; (IPC1-7): C07D231/56; C07D401/04; A61K31/416; A61K31/4439; A61P27/06; A61P43/00
Domestic Patent References:
| WO2001056988A1 | 2001-08-09 | |||
| WO2001053268A2 | 2001-07-26 | |||
| WO1998006433A1 | 1998-02-19 | |||
| WO1997023222A1 | 1997-07-03 | |||
| WO1999064011A1 | 1999-12-16 | |||
| WO2001056988A1 | 2001-08-09 | |||
| WO2002100833A1 | 2002-12-19 | |||
| WO2002076976A2 | 2002-10-03 | |||
| WO2002076977A2 | 2002-10-03 | |||
| WO2000009162A1 | 2000-02-24 | |||
| WO2000057914A1 | 2000-10-05 |
Other References:
NATURE, vol. 389, 1997, pages 990 - 994
KAIBUCHI, J. BIOL. CHEM., vol. 274, 1999, pages 32418
R. A. BARTSCHE ET AL., J. HETEROCYCLIC CHEM., vol. 21, 1984, pages 1063
KAIBUCHI ET AL., J. BIOL. CHEM., vol. 274, 1999, pages 32418
See also references of EP 1679308A4
KAIBUCHI, J. BIOL. CHEM., vol. 274, 1999, pages 32418
R. A. BARTSCHE ET AL., J. HETEROCYCLIC CHEM., vol. 21, 1984, pages 1063
KAIBUCHI ET AL., J. BIOL. CHEM., vol. 274, 1999, pages 32418
See also references of EP 1679308A4
Attorney, Agent or Firm:
Hibi, Norihiko c/o Kishimoto & Co. (3rd Floor Inaba Building, 13-18,
Nishishinsaibashi 1-chome, Chuo-k, Osaka-shi Yamaguchi, JP)
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