Title:
NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2010/064875
Kind Code:
A3
Abstract:
Disclosed are novel indazole derivatives represented by the following Chemical Formula 1 or pharmaceutically acceptable salts, hydrates or solvates thereof, and pharmaceutical compositions for the prevention or treatment of proliferative diseases, containing the same as an active ingredient. Having potent inhibitory effect against protein kinase, such as b-raf, KDR, Fms, Tie2, SAPK2a and Ret, inducing diseases caused by abnormal cell proliferation, the novel indazole derivatives can be used for the prevention or treatment of diseases caused by abnormal cell proliferation.
Inventors:
SIM TAE BO (KR)
SON JUNG BEOM (KR)
KIM HWAN (KR)
PARK DONG SIK (KR)
CHOI HWAN GEUN (KR)
HAM YOUNG JIN (KR)
HAH JUNG MI (KR)
YOO KYUNG HO (KR)
OH CHANG HYUN (KR)
LEE SO HA (KR)
HA JAE DU (KR)
CHO SUNG YUN (KR)
KWON BYOUNG-MOG (KR)
HAN DONG CHO (KR)
SON JUNG BEOM (KR)
KIM HWAN (KR)
PARK DONG SIK (KR)
CHOI HWAN GEUN (KR)
HAM YOUNG JIN (KR)
HAH JUNG MI (KR)
YOO KYUNG HO (KR)
OH CHANG HYUN (KR)
LEE SO HA (KR)
HA JAE DU (KR)
CHO SUNG YUN (KR)
KWON BYOUNG-MOG (KR)
HAN DONG CHO (KR)
Application Number:
PCT/KR2009/007247
Publication Date:
September 10, 2010
Filing Date:
December 04, 2009
Export Citation:
Assignee:
KOREA INST SCI & TECH (KR)
KOREA RES INST CHEM TECH (KR)
KOREA RES INST OF BIOSCIENCE (KR)
SIM TAE BO (KR)
SON JUNG BEOM (KR)
KIM HWAN (KR)
PARK DONG SIK (KR)
CHOI HWAN GEUN (KR)
HAM YOUNG JIN (KR)
HAH JUNG MI (KR)
YOO KYUNG HO (KR)
OH CHANG HYUN (KR)
LEE SO HA (KR)
HA JAE DU (KR)
CHO SUNG YUN (KR)
KWON BYOUNG-MOG (KR)
HAN DONG CHO (KR)
KOREA RES INST CHEM TECH (KR)
KOREA RES INST OF BIOSCIENCE (KR)
SIM TAE BO (KR)
SON JUNG BEOM (KR)
KIM HWAN (KR)
PARK DONG SIK (KR)
CHOI HWAN GEUN (KR)
HAM YOUNG JIN (KR)
HAH JUNG MI (KR)
YOO KYUNG HO (KR)
OH CHANG HYUN (KR)
LEE SO HA (KR)
HA JAE DU (KR)
CHO SUNG YUN (KR)
KWON BYOUNG-MOG (KR)
HAN DONG CHO (KR)
International Classes:
C07D231/56
Domestic Patent References:
| WO2006003276A1 | 2006-01-12 | |||
| WO2003051847A1 | 2003-06-26 |
Other References:
JASON WITHERINGTON ET AL.: "6-Heteroaryl-pyrazolo[3,4-b]pyridines: Potent an d Selective Inhibitors of Glycogen Synthase Kinase-3(GSK-3).", BIOORGANIC & ME DINANAL CHEMISTRY LETTERS., vol. 13, no. 18, 15 September 2003 (2003-09-15), pages 3059 - 3062
Attorney, Agent or Firm:
LEE, Won-Hee (Sung-ji Heights II 642-16,Yoksam-dong, Kangnam-ku, Seoul 135-080, KR)
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