NOVEL INTERMEDIATE FOR SWEETENER WITH HIGH SWEETNESS AND PROCESS FOR PRODUCING THE SAME

Title:

NOVEL INTERMEDIATE FOR SWEETENER WITH HIGH SWEETNESS AND PROCESS FOR PRODUCING THE SAME

Document Type and Number:

WIPO Patent Application WO/2001/038297

Kind Code:

A1

Abstract:

3-(3-Hydroxy-4-methoxyphenyl)-3-methylbutyric acid can be obtained by substituting the substituent at the 3-position of the benzene ring of a butyric acid derivative which can be easily and efficiently produced by reacting a hydroxyl-protected 2-methoxyphenol, wherein the hydroxyl group of 2-methoxyphenol is protected in the form of a sulfonate, with 3-methylcrotonic acid in the presence of an acid. By further converting the carboxyl group into a formyl group, 3-(3-hydroxy-4-methoxyphenyl)-3-methyl butyl aldehyde can be easily produced. This aldehyde derivative can be easily derived into a compound, which is excellent as a sweetener with a high sweetness, by reductive alkylation with Aspartame.

Inventors:

KAWAHARA SHIGERU (JP)
MORI KENICHI (JP)
NAGASHIMA KAZUTAKA (JP)
TAKEMOTO TADASHI (JP)

Application Number:

PCT/JP2000/007913

Publication Date:

May 31, 2001

Filing Date:

November 09, 2000

Export Citation:

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Assignee:

AJINOMOTO KK (JP)
KAWAHARA SHIGERU (JP)
MORI KENICHI (JP)
NAGASHIMA KAZUTAKA (JP)
TAKEMOTO TADASHI (JP)

International Classes:

C07C45/41; C07C47/277; C07C51/367; C07C303/30; C07K5/072; C07K5/075; C07C309/66; (IPC1-7): C07C303/30; C07C309/66; C07C45/41; C07C47/277; C07C51/367; C07C59/64; C07K5/075

Domestic Patent References:

WO1999052937A1	1999-10-21
WO1997034865A1	1997-09-25

Foreign References:

US5705704A

1998-01-06

Other References: