Title:
NOVEL IONIZABLE LIPID USED FOR NUCLEIC ACID DELIVERY AND LNP COMPOSITION THEREOF AND VACCINE
Document Type and Number:
WIPO Patent Application WO/2023/143591
Kind Code:
A1
Abstract:
The present invention provides a novel cationic lipid, a lipid nanoparticle and a nucleic acid vaccine. It is found that the lipid nanoparticle mRNA vaccine prepared in the present invention by selecting a specific cationic lipid has better in-vitro stability and immunogenicity than LNPs prepared from cationic lipids in the prior art.
Inventors:
LI JIN (CN)
WANG HAOMENG (CN)
YAN ZHIHONG (CN)
YUAN JINBO (CN)
LIU JIAN (CN)
YU XUEFENG (CN)
QIU DONGXU (CN)
ZHU TAO (CN)
WANG HAOMENG (CN)
YAN ZHIHONG (CN)
YUAN JINBO (CN)
LIU JIAN (CN)
YU XUEFENG (CN)
QIU DONGXU (CN)
ZHU TAO (CN)
Application Number:
PCT/CN2023/073756
Publication Date:
August 03, 2023
Filing Date:
January 30, 2023
Export Citation:
Assignee:
CANSINO BIOLOGICS INC (CN)
International Classes:
C07C219/06; A61K31/713; A61P31/04; A61P31/10; A61P31/12; A61P35/00; C07C215/14; C07C229/12; C07C233/36; C07C255/24
Domestic Patent References:
| WO2021204175A1 | 2021-10-14 | |||
| WO2021055835A1 | 2021-03-25 | |||
| WO2018225871A1 | 2018-12-13 | |||
| WO2010062322A2 | 2010-06-03 |
Foreign References:
| CN114149337A | 2022-03-08 | |||
| CN114921481A | 2022-08-19 | |||
| US4650865A | 1987-03-17 | |||
| CN109071576A | 2018-12-21 | |||
| JP2005015377A | 2005-01-20 | |||
| CN112375252A | 2021-02-19 | |||
| CN107427531A | 2017-12-01 | |||
| CN102884041A | 2013-01-16 | |||
| CN104066712A | 2014-09-24 | |||
| CN113402405A | 2021-09-17 | |||
| US20200368173A1 | 2020-11-26 | |||
| CN101346468A | 2009-01-14 | |||
| CN108368028A | 2018-08-03 | |||
| CN101616677A | 2009-12-30 | |||
| CN102245559A | 2011-11-16 |
Other References:
LI, LINXIAN ET AL.: "Combinatorial Synthesis and High-Throughput Screening of Alkyl Amines for Nonviral Gene Delivery", BIOCONJUGATE CHEMISTRY, vol. 24, no. 9, 5 August 2013 (2013-08-05), pages 1543 - 1551, XP055262549, ISSN: 1043-1802, DOI: 10.1021/bc400158w
WANG, MING ET AL.: "A Combinatorial Library of Unsaturated Lipidoids for Efficient Intracellular Gene Delivery", ACS SYNTHETIC BIOLOGY, vol. 1, no. 9, 25 May 2012 (2012-05-25), pages 403 - 407, XP008165065, ISSN: 2161-5063, DOI: 10.1021/sb300023h
WANG, MING ET AL.: "A Combinatorial Library of Unsaturated Lipidoids for Efficient Intracellular Gene Delivery", ACS SYNTHETIC BIOLOGY, vol. 1, no. 9, 25 May 2012 (2012-05-25), pages 403 - 407, XP008165065, ISSN: 2161-5063, DOI: 10.1021/sb300023h
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
Download PDF:
Previous Patent: TUMOR COMBINATION THERAPY USING ANTI-IL-11 ANTIBODY
Next Patent: LASER SYSTEM AND LASER MEASUREMENT METHOD
Next Patent: LASER SYSTEM AND LASER MEASUREMENT METHOD