Title:
NOVEL LINKER COMPOUND AND LIGAND-DRUG CONJUGATE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/005461
Kind Code:
A1
Abstract:
The present invention provides a novel linker compound and a ligand-drug conjugate therefor. This can stably deliver an active ingredient to a target site and rapidly release the active ingredient at the target site, and thus can increase efficacy of the active ingredient and can prevent the active ingredient from causing side effects at locations other than the target location.
Inventors:
WOO SUNG HO (KR)
PARK SU HO (KR)
CHO JONG UN (KR)
YUN SANG HYEON (KR)
MIN GYOUNG WOOK (KR)
PARK OK KU (KR)
LEE HYUN MI (KR)
PARK SU HO (KR)
CHO JONG UN (KR)
YUN SANG HYEON (KR)
MIN GYOUNG WOOK (KR)
PARK OK KU (KR)
LEE HYUN MI (KR)
Application Number:
PCT/KR2023/008747
Publication Date:
January 04, 2024
Filing Date:
June 23, 2023
Export Citation:
Assignee:
TRIOAR INC (KR)
International Classes:
A61K47/54; A61K47/68; A61K49/00; A61P35/00; C07D409/14; C07H17/00; C07H17/02; C07H17/04; C07J43/00
Domestic Patent References:
| WO2021016537A1 | 2021-01-28 |
Foreign References:
| KR20180077087A | 2018-07-06 | |||
| KR20180078329A | 2018-07-09 |
Other References:
A. E. M. VICKERS, V. FISCHER, M. S. CONNORS, W. A. BIGGI, F. HEITZ, J-P. BALDECK & K. BRENDEL : "Biotransformation of the antiemetic 5-HT 3 antagonist tropisetron in liver and kidney slices of human, rat and dog with a comparison to in vivo. ", EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS., EDITIONS MEDECINE ET HYGIENE, CHENE-BOURG, CH, vol. 21, no. 1, 1 March 1996 (1996-03-01), CH , pages 43 - 50, XP009551511, ISSN: 0378-7966, DOI: 10.1007/BF03190277
SATO DAISUKE, WU ZHIYUAN, FUJITA HIKARU, LINDSEY JONATHAN: "Design, Synthesis, and Utility of Defined Molecular Scaffolds", ORGANICS, vol. 2, no. 3, 11 July 2021 (2021-07-11), pages 161 - 273, XP093122158, ISSN: 2673-401X, DOI: 10.3390/org2030013
SATO DAISUKE, WU ZHIYUAN, FUJITA HIKARU, LINDSEY JONATHAN: "Design, Synthesis, and Utility of Defined Molecular Scaffolds", ORGANICS, vol. 2, no. 3, 11 July 2021 (2021-07-11), pages 161 - 273, XP093122158, ISSN: 2673-401X, DOI: 10.3390/org2030013
Attorney, Agent or Firm:
RYU, Jong Woo et al. (KR)
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