Title:
NOVEL LL-D49194 Α1 ANALOG, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/177568
Kind Code:
A1
Abstract:
The present invention relates to an LL-D49194α1 analog, a preparation method therefor and an application thereof. Specifically, provided by the present invention is a deglycosylated and demethylated LL-D49194α1 analog. The obtained LL-D49194α1 analog has a better antitumor activity than LL-D49194α1.
Inventors:
TANG GONGLI (CN)
DONG LEI (CN)
HOU XIANFENG (CN)
PAN HAIXUE (CN)
DONG LEI (CN)
HOU XIANFENG (CN)
PAN HAIXUE (CN)
Application Number:
PCT/CN2020/076478
Publication Date:
September 10, 2020
Filing Date:
February 24, 2020
Export Citation:
Assignee:
SHANGHAI INST ORGANIC CHEMISTRY CAS (CN)
International Classes:
C07D493/22; A61K31/357; A61K31/7048; A61P35/00; C07H15/26; C12P17/18; C12R1/465
Domestic Patent References:
| WO2014082065A1 | 2014-05-30 |
Foreign References:
| US4626503A | 1986-12-02 |
Other References:
ZHANG, MEI ET AL.: "Biosynthesis of trioxacarcin revealing a different starter unit and complex tailoring steps for type II polyketide synthase", CHEMICAL SCIENCE, vol. 6, no. 6, 7 April 2015 (2015-04-07), pages 3440 - 3447, XP055736183
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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