Title:
NOVEL LOW-SWELLLING-DEGREE HYDROGEL CONTAINING TEMPERATURE -RESPONSIVE POLYMER
Document Type and Number:
WIPO Patent Application WO/2014/157186
Kind Code:
A1
Abstract:
[Problem] To provide a novel hydrogel composition which exhibits a controlled swelling degree in water and therefore can keep the as-made original shape at the temperature of a human body and which exhibits a high breaking strength. [Solution] A hydrogel composition which comprises, as constituents, both a tetra-armed polymer having a polyethylene glycol skeleton and a temperature-responsive tetra-armed polymer having a phase transition temperature and in which the polymers are crosslinked at the terminals through covalent bonds to form a network structure.
Inventors:
SAKAI TAKAMASA (JP)
TEI YUICHI (JP)
TEI YUICHI (JP)
Application Number:
PCT/JP2014/058249
Publication Date:
October 02, 2014
Filing Date:
March 25, 2014
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
C08G65/329; C08G81/00; C08L71/02; A61L27/00
Domestic Patent References:
| WO2010070775A1 | 2010-06-24 |
Foreign References:
| JP2009029967A | 2009-02-12 | |||
| US5736174A | 1998-04-07 |
Other References:
KAMATA H. ET AL.: "Anomalous volume phase transition in a polymer gel with alternative hydrophilic-amphiphilic sequence", SOFT MATTER, vol. 8, 2012, pages 2876 - 2879
WEINHART M. ET AL.: "Switchable, biocompatible surfaces based on glycerol copolymers", CHEMICAL COMMUNICATIONS, vol. 47, 2011, pages 1553 - 1555
HUYNH C.T. ET AL.: "pH/temperature-sensitive 4-arm poly(ethylene glycol)-poly(amino urethane) copolymer hydrogels", POLYMER, vol. 51, 2010, pages 3843 - 3850
TAKAO AOYAGI ET AL.: "Molecular Design of Novel Polymers and Hydrogels Containing Sensitive Temperature-Response", NETWORK POLYMER, vol. 20, no. 3, 1999, pages 36 - 43
HIROYUKI KAMATA ET AL.: "Takai Dansei Henkeino o Yusuru Hi-Bojun Hydrogel", DAI 22 KAI POLYMER ZAIRYO FORUM YOKOSHU, 13 November 2013 (2013-11-13), pages 32
KAMATA H. ET AL.: "Nonswellable'' Hydrogel Without Mechanical Hysteresis", SCIENCE, vol. 343, 21 February 2014 (2014-02-21), pages 873 - 875
WEINHART M. ET AL.: "Switchable, biocompatible surfaces based on glycerol copolymers", CHEMICAL COMMUNICATIONS, vol. 47, 2011, pages 1553 - 1555
HUYNH C.T. ET AL.: "pH/temperature-sensitive 4-arm poly(ethylene glycol)-poly(amino urethane) copolymer hydrogels", POLYMER, vol. 51, 2010, pages 3843 - 3850
TAKAO AOYAGI ET AL.: "Molecular Design of Novel Polymers and Hydrogels Containing Sensitive Temperature-Response", NETWORK POLYMER, vol. 20, no. 3, 1999, pages 36 - 43
HIROYUKI KAMATA ET AL.: "Takai Dansei Henkeino o Yusuru Hi-Bojun Hydrogel", DAI 22 KAI POLYMER ZAIRYO FORUM YOKOSHU, 13 November 2013 (2013-11-13), pages 32
KAMATA H. ET AL.: "Nonswellable'' Hydrogel Without Mechanical Hysteresis", SCIENCE, vol. 343, 21 February 2014 (2014-02-21), pages 873 - 875
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
Makoto Ono (JP)
Makoto Ono (JP)
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