Title:
NOVEL MANNITOL-BASED AMPHIPATHIC COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/043703
Kind Code:
A1
Abstract:
The present invention relates to a mannitol-based amphipathic compound, a method for preparing the same, a method of extraction, solubilization, stabilization or crystallization of a membrane protein using the same, and a method for analyzing the structure of membrane proteins by means of an electron microscope using the same. Using the mannitol-based compound according to the present invention enables membrane proteins to be stably stored in an aqueous solution for a long time, and the mannitol-based compound can be used for a functional analysis and a structural analysis of the membrane proteins. The structural and functional analyses of membrane proteins are one of the fields of greatest interest in current biology and chemistry, and more than half of new drugs currently under development target membrane proteins, and therefore, are applicable to researches of the structure of membrane proteins which have a close relationship with the development of new drugs.
Inventors:
CHAE PIL SEOK (KR)
HUSSAIN HAZRAT (KR)
HUSSAIN HAZRAT (KR)
Application Number:
PCT/KR2015/013688
Publication Date:
March 16, 2017
Filing Date:
December 14, 2015
Export Citation:
Assignee:
INDUSTRY-UNIV COOP FOUND HANYANG UNIV ERICA CAMPUS (KR)
International Classes:
C07H15/00; C07C43/04; C07H3/02; C07K1/14; G01N1/28; G01N33/68
Foreign References:
| US8263754B2 | 2012-09-11 | |||
| US20130005016A1 | 2013-01-03 | |||
| US20100311956A1 | 2010-12-09 | |||
| US8481691B2 | 2013-07-09 |
Other References:
CHAE, PIL SEOK ET AL.: "New Ganglio-tripod Amphiphiles (TPAs) for Membrane Protein Solubilization and Stabilization: Implications for Detergent Structure-property Relationships", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 12, no. 42, 26 August 2014 (2014-08-26), pages 8480 - 8487, XP055371418
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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