Title:
NOVEL METALLOPROTEASE AND DNA CODING FOR THE SAME
Document Type and Number:
WIPO Patent Application WO/1995/015374
Kind Code:
A1
Abstract:
A novel metalloprotease, a DNA coding for the same, a plasmid having the sequence of the DNA, a host cell having the plasmid, and a monoclonal antibody binding specifically to the protein thereof, being useful in the medical and physiological fields for recognizing the presence of a cancer cell, diagnosing cancer malignancy, and other applications.
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Inventors:
SEIKI MOTOHARU (JP)
SATO HIROSHI (JP)
SHINAGAWA AKIRA (JP)
SATO HIROSHI (JP)
SHINAGAWA AKIRA (JP)
Application Number:
PCT/JP1994/002009
Publication Date:
June 08, 1995
Filing Date:
November 30, 1994
Export Citation:
Assignee:
FUJI YAKUHIN KOGYO KK (JP)
SEIKI MOTOHARU (JP)
SATO HIROSHI (JP)
SHINAGAWA AKIRA (JP)
SEIKI MOTOHARU (JP)
SATO HIROSHI (JP)
SHINAGAWA AKIRA (JP)
International Classes:
C12N9/64; C12N15/57; (IPC1-7): C12N9/64
Other References:
Nature, Vol. 370, No. 6484, July 7, 1994 (07-07-94), HIROSHI SATO et al., "A Matrix Metalloproteinase Expressed on the Surface of Invasive Tumour Cells", p. 61-65.
Journal of Cancer Research Clinical Oncology, Vol. 117, No. 2, (1991), M. SIADAT PAJOUR et al., "Expression of Metalloproteinase Genes in Human Prostate Cancer", p. 144-150.
See also references of EP 0685557A4
CANCER RES., vol. 46, 1986, pages 1 - 7
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 154, 1988, pages 832 - 838
CANCER, vol. 71, 1993, pages 1368 - 1383
J. BIOL. CHEM., vol. 267, 1992, pages 3581 - 3584
NATURE, vol. 370, 1994, pages 61 - 65
"PCR Technology", 1989, STOCKTON PRESS, pages: 63 - 67
T. MANIASTIS ET AL.: "Molecular Cloning, 'a Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS, pages: 2.78
GENE, vol. 25, 1983, pages 263 - 269
"PCR Technology", 1989, STOCKTON PRESS, pages: 63 - 67
T. MANIASTIS ET AL.: "Molecular Cloning, a Laboratory Manual", 1989, COLD SPRING HARBOR: LABORATORY PRESS, pages: 2.78
CANCER RES., vol. 50, 1990, pages 7758 - 7764
"Selected Methods in Cellular Immunology", 1980, W.H. FREEMAN AND COMPANY, pages: 351 - 372
J. BIOL. CHEM., vol. 267, 1992, pages 21712 - 21719
CLIN. CHIM. ACTA, vol. 221, 1993, pages 91 - 103
CLIN. CHIM. ACTA, vol. 211, 1992, pages 59 - 72
CANCER RES., vol. 50, 1990, pages 7758 - 7764
J. BIOL. CHEM., vol. 267, 1992, pages 21712 - 21719
STRONGIN ET AL., J. BIOL. CHEM., vol. 268, 1993, pages 14033 - 14039
CANCER RES, vol. 47, 1987, pages 3239 - 3245
Journal of Cancer Research Clinical Oncology, Vol. 117, No. 2, (1991), M. SIADAT PAJOUR et al., "Expression of Metalloproteinase Genes in Human Prostate Cancer", p. 144-150.
See also references of EP 0685557A4
CANCER RES., vol. 46, 1986, pages 1 - 7
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 154, 1988, pages 832 - 838
CANCER, vol. 71, 1993, pages 1368 - 1383
J. BIOL. CHEM., vol. 267, 1992, pages 3581 - 3584
NATURE, vol. 370, 1994, pages 61 - 65
"PCR Technology", 1989, STOCKTON PRESS, pages: 63 - 67
T. MANIASTIS ET AL.: "Molecular Cloning, 'a Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS, pages: 2.78
GENE, vol. 25, 1983, pages 263 - 269
"PCR Technology", 1989, STOCKTON PRESS, pages: 63 - 67
T. MANIASTIS ET AL.: "Molecular Cloning, a Laboratory Manual", 1989, COLD SPRING HARBOR: LABORATORY PRESS, pages: 2.78
CANCER RES., vol. 50, 1990, pages 7758 - 7764
"Selected Methods in Cellular Immunology", 1980, W.H. FREEMAN AND COMPANY, pages: 351 - 372
J. BIOL. CHEM., vol. 267, 1992, pages 21712 - 21719
CLIN. CHIM. ACTA, vol. 221, 1993, pages 91 - 103
CLIN. CHIM. ACTA, vol. 211, 1992, pages 59 - 72
CANCER RES., vol. 50, 1990, pages 7758 - 7764
J. BIOL. CHEM., vol. 267, 1992, pages 21712 - 21719
STRONGIN ET AL., J. BIOL. CHEM., vol. 268, 1993, pages 14033 - 14039
CANCER RES, vol. 47, 1987, pages 3239 - 3245
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