Title:
NOVEL METALLOPROTEIN AND PROCESS FOR PRODUCING SAME, AND PROPHYLACTIC OR THERAPEUTIC AGENT FOR CORNEAL AND CONJUNCTIVAL DISEASES COMPRISING SAID METALLOPROTEIN
Document Type and Number:
WIPO Patent Application WO/2012/161112
Kind Code:
A1
Abstract:
The present invention provides: a novel metalloprotein, i.e., selenium-lactoferrin; and a process for producing the metalloprotein. Selenium-lactoferrin according to the present invention can be produced suitably by adding a selenium salt to a solution containing lactoferrin and/or apolactoferrin and then subjecting the resultant mixed solution to dialysis or ultrafiltration. Selenium-lactoferrin according to the present invention has an excellent therapeutic effect on corneal and conjunctival diseases, and is suitable for mass production on an industrial scale.
Inventors:
HIGUCHI AKIHIRO (JP)
INOUE HIROYOSHI (JP)
TSUBOTA KAZUO (JP)
INOUE HIROYOSHI (JP)
TSUBOTA KAZUO (JP)
Application Number:
PCT/JP2012/062752
Publication Date:
November 29, 2012
Filing Date:
May 18, 2012
Export Citation:
Assignee:
UNIV KEIO (JP)
KOWA CO (JP)
HIGUCHI AKIHIRO (JP)
INOUE HIROYOSHI (JP)
TSUBOTA KAZUO (JP)
KOWA CO (JP)
HIGUCHI AKIHIRO (JP)
INOUE HIROYOSHI (JP)
TSUBOTA KAZUO (JP)
International Classes:
C07K14/79; C07K1/02; C07K1/34; A61K38/16; A61P27/02
Domestic Patent References:
| WO2006137426A1 | 2006-12-28 |
Foreign References:
| JP2004352669A | 2004-12-16 | |||
| JP2007137817A | 2007-06-07 | |||
| JP2010526873A | 2010-08-05 | |||
| JP4634809B2 | 2011-02-16 | |||
| JP2007137817A | 2007-06-07 |
Other References:
SUZUKI K ET AL., PROGRESS IN RETINAL AND EYE RESEARCH, vol. 22, 2003, pages 113 - 133
OHASHI, Y.: "Corneal Clinical Science", 2003, IGAKU SHOIN, article "2. Superficial punctate keratopathy", pages: 36 - 43
HAMANO M., JAPAN CONTACT LENS SOCIETY JOURNAL, vol. 37, 1995, pages 1 - 6
LONNERDAL B ET AL., AM J CLIN NUTR, vol. 41, 1985, pages 550 - 559
FUJIWARA ET AL., INVEST. OPHTHALMOL. VIS. SCI., vol. 42, 2001, pages 96 - 100
HIGUCHI A; ITO K; DOGRU M; KITAMURA M; MITANI F; KAWAKITA T; OGAWA Y; TSUBOTA K.: "Corneal damage and lacrimal glands dysfunction in a smoking rat model", FREE RADIC BIOL MED., vol. 51, 2011, pages 2210 - 16
OHASHI, Y.: "Corneal Clinical Science", 2003, IGAKU SHOIN, article "2. Superficial punctate keratopathy", pages: 36 - 43
HAMANO M., JAPAN CONTACT LENS SOCIETY JOURNAL, vol. 37, 1995, pages 1 - 6
LONNERDAL B ET AL., AM J CLIN NUTR, vol. 41, 1985, pages 550 - 559
FUJIWARA ET AL., INVEST. OPHTHALMOL. VIS. SCI., vol. 42, 2001, pages 96 - 100
HIGUCHI A; ITO K; DOGRU M; KITAMURA M; MITANI F; KAWAKITA T; OGAWA Y; TSUBOTA K.: "Corneal damage and lacrimal glands dysfunction in a smoking rat model", FREE RADIC BIOL MED., vol. 51, 2011, pages 2210 - 16
Attorney, Agent or Firm:
YUITA, Junji et al. (JP)
Junji Yuita (JP)
Junji Yuita (JP)
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Claims: