Title:
NOVEL METHOD FOR PREPARING RUCAPARIB
Document Type and Number:
WIPO Patent Application WO/2023/013973
Kind Code:
A1
Abstract:
The present invention relates to a novel method for preparing a rucaparib, enabling excellent synthesis yield and reproducibility to be achieved. More particularly, the present invention relates to: a novel preparation method for synthesizing rucaparib through the formation of a heptagonal lactam ring between substituents introduced at positions 3 and 4, after preferentially synthesizing an indole skeleton in which substituents are introduced at positions 2, 3, 4 and 6; and a novel intermediate usable in the preparation thereof.
Inventors:
CHEON CHEOL-HONG (KR)
PARK JINJAE (KR)
PARK JINJAE (KR)
Application Number:
PCT/KR2022/011114
Publication Date:
February 09, 2023
Filing Date:
July 28, 2022
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C07D209/10; A61K31/55; A61P35/00; C07C69/76; C07C225/16; C07D487/04
Domestic Patent References:
| WO2019115000A1 | 2019-06-20 |
Foreign References:
| CN109824677A | 2019-05-31 | |||
| CN110229162A | 2019-09-13 | |||
| US7323562B2 | 2008-01-29 |
Other References:
CHENG CANG, ZUO XIANG, TU DONGDONG, WAN BIN, ZHANG YANGHUI: "Synthesis of 3,4-Fused Tricyclic Indoles through Cascade Carbopalladation and C–H Amination: Development and Total Synthesis of Rucaparib", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 22, no. 13, 2 July 2020 (2020-07-02), US , pages 4985 - 4989, XP093033163, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.0c01513
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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