Title:
NOVEL METHODS FOR THE TREATMENT AND PREVENTION OF ILEUS
Document Type and Number:
WIPO Patent Application WO2001042207
Kind Code:
A3
Abstract:
Novel methods for the treatment and/or prevention of ileus. The methods may comprise administering to a patient an effective amount of a peripheral mu opioid antagonist compound. Preferred compounds for use in the methods include piperidine-N-alkylcarboxylates, quaternary morphinans, opium alkaloid derivatives and quaternary benzomorphans. The methods are particularly suitable for treating and/or preventing postsurgical ileus and postpartum ileus.
Inventors:
FARRAR JOHN J (US)
SCHIED PETER J (US)
SCHMIDT WILLIAM K (US)
CARPENTER RANDALL L (US)
SCHIED PETER J (US)
SCHMIDT WILLIAM K (US)
CARPENTER RANDALL L (US)
Application Number:
PCT/US2000/042313
Publication Date:
May 02, 2002
Filing Date:
November 29, 2000
Export Citation:
Assignee:
ADOLOR CORP (US)
FARRAR JOHN J (US)
SCHIED PETER J (US)
SCHMIDT WILLIAM K (US)
CARPENTER RANDALL L (US)
FARRAR JOHN J (US)
SCHIED PETER J (US)
SCHMIDT WILLIAM K (US)
CARPENTER RANDALL L (US)
International Classes:
C07D221/26; A61K31/00; A61K31/439; A61K31/445; A61K31/451; A61K31/473; A61K31/485; A61K45/00; A61P1/00; A61P43/00; C07D211/22; C07D489/00; C07D489/02; (IPC1-7): A61K31/451; A61K31/4525; A61K31/454; A61K31/4748
Foreign References:
| US5250542A | 1993-10-05 |
Other References:
MACK D.J.: "Paralytic ileus: response to naloxone", BRITISH JOURNAL OF SURGERY, vol. 76, no. 10, October 1989 (1989-10-01), XP002939468
SCHANG ET AL.: "Beneficial effects of naloxone in a patient with intestinal pseudoobstruction", AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 80, no. 6, 1985, XP002939469
SCHANG ET AL.: "Beneficial effects of naloxone in a patient with intestinal pseudoobstruction", AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 80, no. 6, 1985, XP002939469
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