Title:
NOVEL METHOTREXATE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1992/003436
Kind Code:
A1
Abstract:
A compound represented by general formula (A), which is useful as a medicine because it has potent antirheumatic, psoriasis curing and anticancer actions and a reduced toxicity, wherein R?1¿ represents CH¿2?, CH¿2?CH¿2?, CH¿2?O, CH¿2?S or CH¿2?SO; R?2¿ represents hydrogen, C¿1? to C¿4? lower alkyl or benzyl; R?3¿ represents COOR?4¿, NHCOR?5¿, CONR?6¿R?7¿, PO¿3?H¿2? or SO¿3?H; and n represents an integer of 1 to 4.
Inventors:
OHI NOBUHIRO (JP)
MATSUOKA HIROHARU (JP)
MIYAMOTO KATSUHITO (JP)
SUZUKI HIROSHI (JP)
KATO NOBUAKI (JP)
TSUJI KEIICHIRO (JP)
TAKEDA YASUHISA (JP)
MIHARA MASAHIKO (JP)
NISHINA HIROMICHI (JP)
SHIMAOKA SHIN (JP)
AKAMATSU KENICHI (JP)
MATSUOKA HIROHARU (JP)
MIYAMOTO KATSUHITO (JP)
SUZUKI HIROSHI (JP)
KATO NOBUAKI (JP)
TSUJI KEIICHIRO (JP)
TAKEDA YASUHISA (JP)
MIHARA MASAHIKO (JP)
NISHINA HIROMICHI (JP)
SHIMAOKA SHIN (JP)
AKAMATSU KENICHI (JP)
Application Number:
PCT/JP1991/001078
Publication Date:
March 05, 1992
Filing Date:
August 14, 1991
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K31/505; A61K31/535; A61K31/54; A61K31/675; C07D475/08; C07F9/6561; (IPC1-7): A61K31/505; A61K31/535; A61K31/54; A61K31/675; C07D475/08; C07F9/6561
Other References:
J. Med. Chem., Vol. 21, No. 4, April 1978, D.F. WORTH et al. "Folate Antagonists. 10. Synthesis and Antimalarial Effects of 6-(((Aryl and aralyl)amino)methyl)-2,4-pteridinediamines and -pteridin-ediamine 8-Oxides", pages 331-337.
Attorney, Agent or Firm:
Yuasa, Kyozo (Section 206 Shin Ohtemachi Bldg., 2-1,
Ohtemachi 2-chom, Chiyoda-ku Tokyo 100, JP)
Download PDF: