Title:
NOVEL NON-AROMATIC CARBOCYCLIC OR NON-AROMATIC HETEROCYCLIC DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2014/061693
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel compound that has an ACC2 inhibitory activity. Also provided is a medicinal composition containing the compound.
A compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
In formula (I):
the group represented by formula (chemical formula 2) is an unsubstituted aryl, etc.;
substituent group α is substituted or unsubstituted alkyl, etc.;
ring B is a substituted or unsubstituted non-aromatic carbocycle, etc.;
ring C is a substituted or unsubstituted 6-membered aromatic carbocycle, etc.;
U is -CR4R5-, etc.;
T is -CR7R8-, etc.;
L is -CR10R11-, etc.;
p is 0 or 1;
q is 0 or 1;
r is 0 or 1;
R4, R5, R7, R8, R10 and R11 are independently hydrogen, etc.;
R6 and R9 are independently hydrogen or substituted or unsubstituted alkyl;
R13 is substituted or unsubstituted alkyl;
R14 is substituted or unsubstituted alkylcarbonyl, etc.; and
R16 is hydrogen or substituted or unsubstituted alkyl.
Inventors:
MATSUMURA AKIRA (JP)
MASUDA KOJI (JP)
ASAHI KENTARO (JP)
IWATSU MASAFUMI (JP)
OHYABU NAOKI (JP)
SASAKI YOSHIKAZU (JP)
MASUDA KOJI (JP)
ASAHI KENTARO (JP)
IWATSU MASAFUMI (JP)
OHYABU NAOKI (JP)
SASAKI YOSHIKAZU (JP)
Application Number:
PCT/JP2013/078047
Publication Date:
April 24, 2014
Filing Date:
October 16, 2013
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D205/04; A61K31/397; A61K31/42; A61K31/423; A61K31/4245; A61K31/427; A61K31/428; A61K31/437; A61K31/4439; A61K31/451; A61K31/454; A61K31/506; A61K31/5377; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P5/50; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P25/00; A61P27/02; A61P31/00; A61P35/00; C07D211/46; C07D261/08; C07D271/06; C07D271/10; C07D277/28; C07D413/04; C07D413/08; C07D413/12; C07D413/14; C07D417/04; C07D417/12; C07D417/14; C07D487/04
Domestic Patent References:
| WO2012001107A1 | 2012-01-05 | |||
| WO2013098373A1 | 2013-07-04 | |||
| WO2013098375A1 | 2013-07-04 | |||
| WO2013092616A1 | 2013-06-27 |
Foreign References:
| JP2010138082A | 2010-06-24 |
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
Hiromitsu Takayama (JP)
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