Title:
NOVEL NUCLEAR TRANSLOCATION PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2008/108505
Kind Code:
A1
Abstract:
Disclosed is a peptide comprising amino acid sequences RI, FI and RIGC and is composed of 25 or less amino acid residues, which can transport a functional molecule into the inside of a cell as well as into the inside of a nucleus more efficiently compared to a conventional PTD.
Inventors:
ISHIZAKA YUKIHITO (JP)
HASEGAWA MASAKATSU (JP)
NOHARA SATOSHI (JP)
HASEGAWA MASAKATSU (JP)
NOHARA SATOSHI (JP)
Application Number:
PCT/JP2008/054563
Publication Date:
September 12, 2008
Filing Date:
March 06, 2008
Export Citation:
Assignee:
JAPAN GOVERNMENT (JP)
MEITO SANGYO KK (JP)
ISHIZAKA YUKIHITO (JP)
HASEGAWA MASAKATSU (JP)
NOHARA SATOSHI (JP)
MEITO SANGYO KK (JP)
ISHIZAKA YUKIHITO (JP)
HASEGAWA MASAKATSU (JP)
NOHARA SATOSHI (JP)
International Classes:
C07K7/08; A61K41/00; A61K47/48; C07K7/06; C07K9/00; C07K14/16
Foreign References:
| US0565211A | 1896-08-04 | |||
| JP2939336B2 | 1999-08-25 | |||
| US4452773A | 1984-06-05 | |||
| JP2726520B2 | 1998-03-11 | |||
| JP2006306784A | 2006-11-09 |
Other References:
TAGUCHI, T. ET AL.: "Nuclear trafficking of macromolecules by an oligopeptide derived from Vpr of human immunodeficiency virus type-1, Biochem", BIOPHYS. RES. COMMUN., vol. 320, no. 1, July 2004 (2004-07-01), pages 18 - 26, XP004519059
MASAKATSU HASEGAWA: "Jisei Nano Ryushi eno Peptide Fuka, Saitekika ni Kansuru Kenkyu", PEPTIDE FUKAGATA KAN'ONSEI NANOMICELLE OYOBI KOSHUHA SHOTEN SHOSHA NI YORU KYOKUSHO DDS NO KAIHATSU NO TAME NO KIBAN KENKYU HEISEI 17 NENDO SOKATSU KENKYU HOKOKUSHO, 2006, pages 8 - 9
MIZOGUCHI, 1. ET AL.: "Improved gene expression in resting macrophages using an oligopeptide derived from Vpr of human immunodeficiency virus type-1", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 338, no. 3, 15 November 2005 (2005-11-15), pages 1499 - 1506, XP027218589
MASAKATSU HASEGAWA: "Jisei Nano Ryushi eno Peptide Fuka, Saitekika ni Kansuru Kenkyu", HYOTEKI PEPTIDE FUKAGATA KAN'ONSEI NANOMICELLE OYOBI KOSHUHA SHOTEN SHOSHA NI YORU KYOKUSHO DDS NO KAIHATSU' NI KANSURU KENKYU HEISEI 18 NENDO SOKATSU KENKYU NENDO SHURYO HOKOKUSHO, March 2007 (2007-03-01), pages 9 - 10
E. VIVES ET AL., J. BIOLOGICAL CHEMISTRY, vol. 272, no. 25, 1997, pages 16010
D. DEROSSI ET AL., J. BIOLOGICAL CHEMISTRY, vol. 271, no. 30, 1996, pages 18188
G. ELLIOT ET AL., CELL, vol. 88, 1997, pages 223
M. ZHAO ET AL., BICONJUGATE CHEM., vol. 13, 2002, pages 840
Y. MUKAI ET AL., BIOL. PHARM. BULL., vol. 29, no. 8, 2006, pages 1570
T. TAGUCHI ET AL., BIOCHEM. BIOPHYS. RES. COMM., vol. 320, 2004, pages 18
MARRIFIELD, J., AM. CHEM. SOC., vol. 85, 1963, pages 2149 - 2154
METHODS IN ENZYMOLOGY, vol. 154, no. 350, 1987, pages 367 - 382
See also references of EP 2130837A4
MASAKATSU HASEGAWA: "Jisei Nano Ryushi eno Peptide Fuka, Saitekika ni Kansuru Kenkyu", PEPTIDE FUKAGATA KAN'ONSEI NANOMICELLE OYOBI KOSHUHA SHOTEN SHOSHA NI YORU KYOKUSHO DDS NO KAIHATSU NO TAME NO KIBAN KENKYU HEISEI 17 NENDO SOKATSU KENKYU HOKOKUSHO, 2006, pages 8 - 9
MIZOGUCHI, 1. ET AL.: "Improved gene expression in resting macrophages using an oligopeptide derived from Vpr of human immunodeficiency virus type-1", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 338, no. 3, 15 November 2005 (2005-11-15), pages 1499 - 1506, XP027218589
MASAKATSU HASEGAWA: "Jisei Nano Ryushi eno Peptide Fuka, Saitekika ni Kansuru Kenkyu", HYOTEKI PEPTIDE FUKAGATA KAN'ONSEI NANOMICELLE OYOBI KOSHUHA SHOTEN SHOSHA NI YORU KYOKUSHO DDS NO KAIHATSU' NI KANSURU KENKYU HEISEI 18 NENDO SOKATSU KENKYU NENDO SHURYO HOKOKUSHO, March 2007 (2007-03-01), pages 9 - 10
E. VIVES ET AL., J. BIOLOGICAL CHEMISTRY, vol. 272, no. 25, 1997, pages 16010
D. DEROSSI ET AL., J. BIOLOGICAL CHEMISTRY, vol. 271, no. 30, 1996, pages 18188
G. ELLIOT ET AL., CELL, vol. 88, 1997, pages 223
M. ZHAO ET AL., BICONJUGATE CHEM., vol. 13, 2002, pages 840
Y. MUKAI ET AL., BIOL. PHARM. BULL., vol. 29, no. 8, 2006, pages 1570
T. TAGUCHI ET AL., BIOCHEM. BIOPHYS. RES. COMM., vol. 320, 2004, pages 18
MARRIFIELD, J., AM. CHEM. SOC., vol. 85, 1963, pages 2149 - 2154
METHODS IN ENZYMOLOGY, vol. 154, no. 350, 1987, pages 367 - 382
See also references of EP 2130837A4
Attorney, Agent or Firm:
Patent Profession Corporation Odajima Patent Office (9-15 Akasaka 1-chome, Minato-k, Tokyo 52, JP)
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