Title:
NOVEL OXA- OR AZASTEROID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1992/017489
Kind Code:
A1
Abstract:
A compound represented by general formula (I), which has an aromatase inhibitory activity and is useful for preventing and treating diseases caused by hyperestrogenosis, such as mastocarcinoma, metrocarcinoma and prostatomegaly. In formula (I) A represents C=O, CH�2?, C=CH�2? or C=CH-lower alkyl; B represents O, NH or N-lower alkyl; X is nil, or represents C=O or CH�2?; n is 2 or 3 when X is nil, or 1 or 2 when X represents C=O or CH�2?; and the broken line between the 1-position and the 2-position in the steroidal skeleton means an optional presence of a double bond therebetween.
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Inventors:
KOIZUMI NAOYUKI (JP)
TAKEGAWA SHIGEHIRO (JP)
IWASHITA SHIGEKI (JP)
KAWACHI TOMOKO (JP)
MATSUI TERUAKI (JP)
HONMA SEIJIRO (JP)
TAKEGAWA SHIGEHIRO (JP)
IWASHITA SHIGEKI (JP)
KAWACHI TOMOKO (JP)
MATSUI TERUAKI (JP)
HONMA SEIJIRO (JP)
Application Number:
PCT/JP1992/000364
Publication Date:
October 15, 1992
Filing Date:
March 26, 1992
Export Citation:
Assignee:
TEIKOKU HORMONE MFG CO LTD (JP)
International Classes:
C07J73/00; (IPC1-7): A61K31/58; C07J73/00
Foreign References:
| US4596797A | 1986-06-24 | |||
| US4591585A | 1986-05-27 | |||
| US4235893A | 1980-11-25 |
Other References:
See also references of EP 0582713A4
Attorney, Agent or Firm:
Odajima, Heikichi (Nippon Jitensha Bldg. 9-15, Akasaka 1-chom, Minato-ku Tokyo 107, JP)
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