Title:
NOVEL PEPTIDE SY
Document Type and Number:
WIPO Patent Application WO/2003/055901
Kind Code:
A1
Abstract:
A peptide SY is produced by applying peptides, which have been obtained by treating fish meat with protease, to a peptide−adsorbing resin (ODS resin, etc.), then eluting successively with a 11 to 18 V&sol V % aqueous solution of ethanol and water, and combining a fraction (1) obtained after eluting with water and another fraction (2) obtained by eluting with the 11 to 18 V&sol V % aqueous solution of ethanol and water. Also, a peptide SY−MD is produced by isolating a fraction eluted with 11 to 18 V&sol V % aqueous solution of ethanol alone. The peptide SY and the peptide SY−MD are both novel peptide mixtures which contain a large amount of a newly found hypotensive peptide Val−Tyr, show little bitterness and have excellent taste and safety. Thus, these peptides are usable as hypotensive drugs, blood pressure increase inhibitors and functional foods aiming at preventing an increase in blood pressure.
Inventors:
OSAJIMA KATSUHIRO (JP)
OOISHI YASUNORI (JP)
OOISHI YASUNORI (JP)
Application Number:
PCT/JP2002/013441
Publication Date:
July 10, 2003
Filing Date:
December 24, 2002
Export Citation:
Assignee:
SENMI EKISU CO LTD (JP)
OSAJIMA KATSUHIRO (JP)
OOISHI YASUNORI (JP)
OSAJIMA KATSUHIRO (JP)
OOISHI YASUNORI (JP)
International Classes:
A23J1/04; A23L1/305; A23L2/66; A61K38/01; A61K38/05; A61K38/55; A61P9/12; A61P43/00; C07K1/20; C07K2/00; C07K5/06; C07K14/46; A61K38/00; (IPC1-7): C07K5/062; C07K1/20; C07K14/46; A23L1/305; A61K38/55; A61P9/12; A61P43/00
Foreign References:
| EP1094071A1 | 2001-04-25 | |||
| JPH07215889A | 1995-08-15 | |||
| EP0445606A1 | 1991-09-11 |
Other References:
HIDEHARU SEKI ET AL.: "Iwashi tanpakushitsu yurai sardine peptide no ketsuatsu koka sayo to riyo no genjo", FOOD PROCESSING, vol. 35, no. 9, September 2000 (2000-09-01), pages 63 - 64, XP002962917
MATSUDA H. ET AL.: "Angiotensin I converting enzyme inhibitory peptides generated from sardin muscle by protease for food industry", NIPPON SHOKUHIN KOGYO GAKKAISHI, vol. 39, no. 8, 1992, pages 678 - 683, XP002096408
UKEDA H. ET AL.: "Peptides from peptic hydrolyzate of heated sardine meat that inhibit angiotensin I converting enzyme", NIPPON NOHEIKAGAKU KAISHI, vol. 66, no. 1, 1992, pages 25 - 29, XP002962918
MATSUDA H. ET AL.: "Angiotensin I converting enzyme inhibitory peptides generated from sardin muscle by protease for food industry", NIPPON SHOKUHIN KOGYO GAKKAISHI, vol. 39, no. 8, 1992, pages 678 - 683, XP002096408
UKEDA H. ET AL.: "Peptides from peptic hydrolyzate of heated sardine meat that inhibit angiotensin I converting enzyme", NIPPON NOHEIKAGAKU KAISHI, vol. 66, no. 1, 1992, pages 25 - 29, XP002962918
Attorney, Agent or Firm:
Toda, Chikao (1-19-14 Toranomon Minato-ku, Tokyo, JP)
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