Title:
NOVEL PEPTIDE SYNTHASE GENE
Document Type and Number:
WIPO Patent Application WO/2004/011653
Kind Code:
A1
Abstract:
A novel enzyme by which a peptide can be conveniently and economically produced at a high yield without via a complicated synthesis process. More specifically, it is intended to provide a novel enzyme catalyzing a peptide synthesis reaction from a carboxy component and an amine component, a microorganism producing this enzyme, and a process for economically producing a peptide with the use of the enzyme or the microorganism. From a newly found bacterium belonging to the genus Empedobacter, a novel enzyme efficiently synthesizing a peptide is found out. Also, a process for economically and conveniently producing a peptide is found out.
Inventors:
HARA SEIICHI (JP)
YOKOZEKI KENZO (JP)
ABE ISAO (JP)
TONOUCHI NAOTO (JP)
JOJIMA YASUKO (JP)
YOKOZEKI KENZO (JP)
ABE ISAO (JP)
TONOUCHI NAOTO (JP)
JOJIMA YASUKO (JP)
Application Number:
PCT/JP2003/009468
Publication Date:
February 05, 2004
Filing Date:
July 25, 2003
Export Citation:
Assignee:
AJINOMOTO KK (JP)
HARA SEIICHI (JP)
YOKOZEKI KENZO (JP)
ABE ISAO (JP)
TONOUCHI NAOTO (JP)
JOJIMA YASUKO (JP)
HARA SEIICHI (JP)
YOKOZEKI KENZO (JP)
ABE ISAO (JP)
TONOUCHI NAOTO (JP)
JOJIMA YASUKO (JP)
International Classes:
C12N1/21; C12N9/00; C12N15/57; C12P21/02; (IPC1-7): C12N15/57; C12N1/21; C12N9/48; C12P21/02
Domestic Patent References:
| WO2000058478A1 | 2000-10-05 | |||
| WO1999061050A1 | 1999-12-02 | |||
| WO2003010307A1 | 2003-02-06 | |||
| WO2003010187A1 | 2003-02-06 | |||
| WO2003001089A1 | 2003-01-03 |
Foreign References:
| JP2000078971A | 2000-03-21 |
Other References:
KRIEG F. ET AL.: "Enzymatic peptide synthesis by the recombinant proline-specific endopeptidase from flavobacterium mening osepticum and its mutationally altered Cys-556 variant", APPL. MICROBIOL. BIOTECHNOL., vol. 42, no. 6, March 1995 (1995-03-01), pages 844 - 852, XP002974151
TETRAHEDRON LETTERS, vol. 22, 1981, pages 1859
APPL. ENVIRON. MICROBIOL., vol. 68, no. 1, 2002, pages 211 - 218
J. BACTERIOL., vol. 173, no. 24, 1991, pages 7848 - 7855
TETRAHEDRON LETTERS, vol. 22, 1981, pages 1859
APPL. ENVIRON. MICROBIOL., vol. 68, no. 1, 2002, pages 211 - 218
J. BACTERIOL., vol. 173, no. 24, 1991, pages 7848 - 7855
Attorney, Agent or Firm:
Sakai, Hiroaki (2-6 Kasumigaseki 3-chom, Chiyoda-ku Tokyo, JP)
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