Title:
NOVEL PHENYLACETIC ACID DERIVATIVE, PREPARATION METHOD THEREOF AND USE THEREOF AS DRUG
Document Type and Number:
WIPO Patent Application WO/2021/036495
Kind Code:
A1
Abstract:
The present invention relates to a novel deuterated 3-pentylphenylacetic acid derivative represented by general formula (I), a preparation method thereof, and a use of a pharmaceutical composition containing the derivative in preparation of a drug for preventing or/and treating organ fibrosis-associated diseases. The compound of the present invention has more excellent drug metabolism properties and anti-organ fibrosis effect in vivo, and can be applied to the preparation of drugs for preventing and/or treating fatty liver, hepatic fibrosis, pulmonary fibrosis, renal fibrosis, cardiac fibrosis, Alström syndrome and other organ fibrosis associated diseases, and has a wide application prospect.
Inventors:
LI ZHENG (CN)
ZHANG LUYONG (CN)
LIU BING (CN)
ZHANG LUYONG (CN)
LIU BING (CN)
Application Number:
PCT/CN2020/099650
Publication Date:
March 04, 2021
Filing Date:
July 01, 2020
Export Citation:
Assignee:
UNIV GUANGDONG PHARM (CN)
International Classes:
C07C57/30; A61K31/192; A61P11/00; A61P19/04
Domestic Patent References:
| WO2012097428A1 | 2012-07-26 |
Foreign References:
| CN105143170A | 2015-12-09 | |||
| CN102421742A | 2012-04-18 |
Attorney, Agent or Firm:
NANJING IPZHI INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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