Title:
NOVEL PHENYLALANINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2003/053926
Kind Code:
A1
Abstract:
A phenylalanine derivative represented by the following formula, its analog and pharmaceutically acceptable salts thereof show an &agr 4 integrin inhibitory activity. These compounds are usable as remedies or preventives for various diseases, for example, in which the &agr 4 integrin-dependent adhesion process relating to &agr 4 integrin participates in pathological conditions, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, multiple sclerosis, Soegren’s syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arteriosclerosis, restenosis, tumor proliferation, tumor metastasis or rejection in transplantation. (13) wherein R1 represents methyl; and R2 represents methoxy.
Inventors:
OKUZUMI TATSUYA (JP)
SAGI KAZUYUKI (JP)
YOSHIMURA TOSHIHIKO (JP)
TANAKA YUJI (JP)
NAKANISHI EIJI (JP)
ONO MIHO (JP)
MURATA MASAHIRO (JP)
SAGI KAZUYUKI (JP)
YOSHIMURA TOSHIHIKO (JP)
TANAKA YUJI (JP)
NAKANISHI EIJI (JP)
ONO MIHO (JP)
MURATA MASAHIRO (JP)
Application Number:
PCT/JP2002/013070
Publication Date:
July 03, 2003
Filing Date:
December 13, 2002
Export Citation:
Assignee:
AJINOMOTO KK (JP)
OKUZUMI TATSUYA (JP)
SAGI KAZUYUKI (JP)
YOSHIMURA TOSHIHIKO (JP)
TANAKA YUJI (JP)
NAKANISHI EIJI (JP)
ONO MIHO (JP)
MURATA MASAHIRO (JP)
OKUZUMI TATSUYA (JP)
SAGI KAZUYUKI (JP)
YOSHIMURA TOSHIHIKO (JP)
TANAKA YUJI (JP)
NAKANISHI EIJI (JP)
ONO MIHO (JP)
MURATA MASAHIRO (JP)
International Classes:
A61K31/403; A61K31/4375; A61K31/47; A61K31/4709; A61K31/472; A61K31/502; A61K31/517; A61P1/00; A61P3/10; A61P9/00; A61P9/10; A61P11/06; A61P17/06; A61P25/00; A61P29/00; A61P35/00; A61P35/04; A61P37/02; A61P37/06; A61P43/00; C07D209/48; C07D215/22; C07D215/227; C07D215/36; C07D215/38; C07D237/32; C07D239/96; C07D401/12; C07D403/12; C07D471/04; (IPC1-7): C07D209/48; C07D215/22; C07D217/24; C07D237/32; C07D239/96; C07D401/12; C07D471/04; A61K31/403; A61K31/4375; A61K31/47; A61K31/472; A61K31/4709; A61K31/502; A61K31/517; A61P1/00; A61P3/10; A61P9/00; A61P9/10; A61P11/06; A61P17/06; A61P25/00; A61P29/00; A61P35/00; A61P35/04; A61P37/02; A61P37/06; A61P43/00
Domestic Patent References:
| WO2002028830A1 | 2002-04-11 | |||
| WO2002016329A1 | 2002-02-28 | |||
| WO2001036376A1 | 2001-05-25 | |||
| WO1999037618A1 | 1999-07-29 | |||
| WO1999035163A1 | 1999-07-15 | |||
| WO1999010313A1 | 1999-03-04 | |||
| WO1999010312A1 | 1999-03-04 |
Other References:
TILLEY J.W. ET AL., BIOORG. MED. CHEM. LETT., vol. 11, no. 1, 2001, pages 1 - 4, XP004225309
Attorney, Agent or Firm:
Nakamura, Minoru (3-1 Marunouchi 3-Chom, Chiyoda-Ku Tokyo, JP)
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