Title:
NOVEL PHENYLESTER COMPOUND AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING INFLAMMATORY DISEASES COMPRISING THE SAME
Document Type and Number:
WIPO Patent Application WO/2013/012118
Kind Code:
A1
Abstract:
The present invention relates to a novel compound, named 2-ethoxy-4-(3-hydroxy-2-oxopropyl) phenyl 2-oxoacetate or a pharmaceutically acceptable salt thereof, which shows anti-inflammatory activity, and a method for preparing the same. Also, a pharmaceutical composition for preventing or treating inflammatory diseases, having the compound or a pharmaceutically acceptable salt thereof as an active ingredient is disclosed. Having therapeutic activity for inflammatory diseases, the phenylester compound is also applicable to a quasi-drug composition, a health functional food composition, and a cosmetic composition, all of which are intended to prevent or improve inflammation. Also, a method is provided for treating an inflammatory disease by administering the pharmaceutical composition to a subject in need thereof. As a natural materials, the novel phenylester compound can be used as a safe therapeutic relatively free of fungal infection or other side-effects, compared to synthetic medicines.
Inventors:
LEE JEONG MIN (KR)
CHOI JUNG HO (KR)
CHOI JI NA (KR)
CHOI YUN HYEOK (KR)
NOH ILL CHAN (KR)
CHOI JUNG HO (KR)
CHOI JI NA (KR)
CHOI YUN HYEOK (KR)
NOH ILL CHAN (KR)
Application Number:
PCT/KR2011/006096
Publication Date:
January 24, 2013
Filing Date:
August 18, 2011
Export Citation:
Assignee:
SINIL PHARMACEUTICAL CO LTD (KR)
LEE JEONG MIN (KR)
CHOI JUNG HO (KR)
CHOI JI NA (KR)
CHOI YUN HYEOK (KR)
NOH ILL CHAN (KR)
LEE JEONG MIN (KR)
CHOI JUNG HO (KR)
CHOI JI NA (KR)
CHOI YUN HYEOK (KR)
NOH ILL CHAN (KR)
International Classes:
C07C69/736; A61K31/216; A61K36/65; A61P29/00
Domestic Patent References:
| WO2002049589A1 | 2002-06-27 |
Foreign References:
| KR20000067187A | 2000-11-15 |
Other References:
CHOI, YUN-HYEOK ET AL.: "Bioassay-guided Isolation of Novel Compound from Paeonia suffruticosa Andrews Roots as an IL-lb Inhibitor", ARCH. PHARM. RES. 2012, vol. 35, 29 May 2012 (2012-05-29), pages 801 - 805
CHUN, SEOUNG-CHUL ET AL.: "Anti-Inflammatory Activity of the Methanol Extract of Moutan Cortex in LPS-Activated Raw 264.7 Cells", EVID BASED COMPLEMENT ALTERNAT. MED., vol. 4, 2007, pages 327 - 333
CHUN, SEOUNG-CHUL ET AL.: "Anti-Inflammatory Activity of the Methanol Extract of Moutan Cortex in LPS-Activated Raw 264.7 Cells", EVID BASED COMPLEMENT ALTERNAT. MED., vol. 4, 2007, pages 327 - 333
Attorney, Agent or Firm:
SON, Min (6th Floor City Air Tower,159-9 Samseong-dong,Gangnam-gu, Seoul 135-973, KR)
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Claims: