Title:
NOVEL PHYSIOLGICALLY ACTIVE SUBSTANCES
Document Type and Number:
WIPO Patent Application WO/2003/099813
Kind Code:
A1
Abstract:
Compounds represented by the following general formula (I), pharmaceutically acceptable salts thereof or hydrates of the same: (I) wherein R3, R6, R7 and R21 are the same or different and each represents hydroxy, etc. Because of inhibiting angiogenesis (in particular, VEGF production in hypoxia), the compounds (I) are useful as remedies for solid cancer.
Inventors:
KOTAKE YOSHIHIKO (JP)
NIIJIMA JUN (JP)
FUKUDA YOSHIO (JP)
NAGAI MITSUO (JP)
KANADA REGINA MIKIE (JP)
NAKASHIMA TAKASHI (JP)
YOSHIDA MASASHI (JP)
TSUCHIDA TOSHIO (JP)
NIIJIMA JUN (JP)
FUKUDA YOSHIO (JP)
NAGAI MITSUO (JP)
KANADA REGINA MIKIE (JP)
NAKASHIMA TAKASHI (JP)
YOSHIDA MASASHI (JP)
TSUCHIDA TOSHIO (JP)
Application Number:
PCT/JP2003/006779
Publication Date:
December 04, 2003
Filing Date:
May 29, 2003
Export Citation:
Assignee:
MERCIAN CORP (JP)
EISAI CO LTD (JP)
KOTAKE YOSHIHIKO (JP)
NIIJIMA JUN (JP)
FUKUDA YOSHIO (JP)
NAGAI MITSUO (JP)
KANADA REGINA MIKIE (JP)
NAKASHIMA TAKASHI (JP)
YOSHIDA MASASHI (JP)
TSUCHIDA TOSHIO (JP)
EISAI CO LTD (JP)
KOTAKE YOSHIHIKO (JP)
NIIJIMA JUN (JP)
FUKUDA YOSHIO (JP)
NAGAI MITSUO (JP)
KANADA REGINA MIKIE (JP)
NAKASHIMA TAKASHI (JP)
YOSHIDA MASASHI (JP)
TSUCHIDA TOSHIO (JP)
International Classes:
A61K31/336; A61K31/366; A61K31/4025; A61K31/4427; A61K31/4523; A61K31/454; A61K31/4545; A61K31/496; A61K31/5377; A61K31/551; A61P9/10; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P43/00; C07D405/14; C07D407/06; C07D407/14; C07D487/04; C07D487/08; C07D; (IPC1-7): C07D405/14; C07D407/06; C07D407/14; C07D487/04; C07D487/08; A61K31/336; A61K31/366; A61K31/4025; A61K31/4427; A61K31/4523; A61K31/454; A61K31/4545; A61K31/496; A61K31/5377; A61K31/551; A61P9/10; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P43/00
Domestic Patent References:
| WO2002060890A1 | 2002-08-08 | |||
| WO2000075126A1 | 2000-12-14 | |||
| WO2002060890A1 | 2002-08-08 |
Foreign References:
| JPH04352783A | 1992-12-07 | |||
| JPH04352783A | 1992-12-07 |
Other References:
SEKI-ASANO M. ET AL., J. ANTIBIOTICS, vol. 47, 1994, pages 1395 - 1401
T. W. GREENE: "Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC.
GOTO ET AL., MOL. PHARMACOL., vol. 49, 1996, pages 860 - 873
CELL. MOL. BIOL. RES., vol. 40, 1994, pages 35 - 39
See also references of EP 1508570A4
T. W. GREENE: "Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC.
GOTO ET AL., MOL. PHARMACOL., vol. 49, 1996, pages 860 - 873
CELL. MOL. BIOL. RES., vol. 40, 1994, pages 35 - 39
See also references of EP 1508570A4
Attorney, Agent or Firm:
Furuya, Satoshi (2-17-8 Nihonbashi-Hamach, Chuo-ku Tokyo, JP)
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